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Antiviral Activity of Lactoferrin

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Advances in Lactoferrin Research

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 443))

Abstract

In 1976, Matthews et al.19 reported the antiviral activity of milk proteins, underlining their possible clinical importance. Only recently, this effect has been ascribed mainly to lactoferrin (Lf). Lf was initially shown to exert a protective influence in mice infected with Friend leukemia virus15. Subsequently, a potent antiviral activity has been attributed to Lf, both in vitro towards cytomegalovirus (HCMV)9,7, herpes simplex virus (HSV)17, human immunodeficiency virus (HIV)7,29 and in vivo towards HSV-16 and HCMV25. Our groups provided evidence on the antiviral activity of Lf towards HSV-218, rotavirus28, and HIV22 infections (Table 1).

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Author information

Authors and Affiliations

  1. Institute of Microbiology, II University of Naples, Italy

    Piera Valenti

  2. Institute of Microbiology, University of Rome “La Sapienza”, Italy

    Magda Marchetti & Lucilla Seganti

  3. Department of Ultrastructures, National Institute of Health, Rome, Italy

    Fabiana Superti & Maria Grazia Amendolia

  4. Laboratory of Immunology, National Institute of Health, Rome, Italy

    Patrizia Puddu

  5. Laboratory of Virology, National Institute of Health, Rome, Italy

    Sandra Gessani, Paola Borghi & Filippo Belardelli

  6. Department of Basic and Applied Biology, University of l’Aquila, Italy

    Giovanni Antonini

Authors
  1. Piera Valenti
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  2. Magda Marchetti
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  3. Fabiana Superti
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  4. Maria Grazia Amendolia
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  5. Patrizia Puddu
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  6. Sandra Gessani
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  7. Paola Borghi
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  8. Filippo Belardelli
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  9. Giovanni Antonini
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  10. Lucilla Seganti
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Editor information

Editors and Affiliations

  1. Université des Sciences et Technologies de Lille, Villeneuve d’Ascq, France

    Geneviève Spik , Dominique Legrand , Joël Mazurier  & Annick Pierce , ,  & 

  2. Biopole, Brussels, Belgium

    Jean-Paul Perraudin

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© 1998 Springer Science+Business Media New York

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Valenti, P. et al. (1998). Antiviral Activity of Lactoferrin. In: Spik, G., Legrand, D., Mazurier, J., Pierce, A., Perraudin, JP. (eds) Advances in Lactoferrin Research. Advances in Experimental Medicine and Biology, vol 443. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9068-9_23

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  • DOI: https://doi.org/10.1007/978-1-4757-9068-9_23

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9070-2

  • Online ISBN: 978-1-4757-9068-9

  • eBook Packages: Springer Book Archive

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