Abstract
Numerous diseases of the central nervous system (CNS) are associated with cholinergic deficits, Alzheimer’s disease being a notable example of such neurodegenerative disorders (Wurtman, 1992). To dissect the molecular mechanisms involved in the impairment of cholinergic neurotransmission in this and other CNS diseases, experimental approaches should be pursued which combine in vivo model systems with sensitive, multileveled detection methods.
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Lev-Lehman, E., El-Tamer, A., Ginzberg, D., Hanin, I., Soreq, H. (1995). Transient Alterations in the in Vivo Levels of Cholinesterase mRNAS Suggest Differential Adjustment to Cholinotoxic Stimuli. In: Hanin, I., Yoshida, M., Fisher, A. (eds) Alzheimer’s and Parkinson’s Diseases. Advances in Behavioral Biology, vol 44. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9145-7_52
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DOI: https://doi.org/10.1007/978-1-4757-9145-7_52
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