Summary
In a 3 year period 359/3685 patients with suspected vasculitis had a positive ANCA-IF. C-ANCA were found in 146/359 and p-ANCA in 213/359 patients. PANCA and MPO-antibodies were more frequently associated with female gender and preglomerular vasculitis, whereas c-ANCA (WG) were more frequent in males without renal vasculitis.
Detection of anti-neutrophil cytoplasmic antibodies (ANCA) has facilitated the diagnosis of Wegener’s granulomatosis (WG) and microscopic polyarteritis (MP), important representatives of small vessel vasculitides (SVV). C-ANCA with proteinase 3 antibodies (PR 3-AB) are typical of WG and p-ANCA with myeloperoxidase antibodies (MPO-AB) are typical of MP in our country. We reported recently (1) about an association between crescentic glomerulonephritis, renal vasculitis, p-ANCA, myeloperoxidase-AB and female gender in a small cohort of patients with rapidly progressive glomerulonephritis (RPGN). In the following we analyzed whether in a larger cohort of patients with SVV this preliminary statements could be confirmed.
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References
Rasmussen, N., Sjoelin, C., Isaksson, B., Bygren, P., Wieslander, J., 1990, An Elisa for the detection of antineutrophil cytoplasm antibodies, J.Irnmunol.Meth. 127: 139–145
Andrassy, K., Koderisch, J., Schaefer, A., Waldherr, R.,1990, Idiopathic rapidly progressive crescentic glomerulonephritis with myeloperoxidase antibodies–a new entitiy linked to female sex? Nephron 56: 99–100
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© 1993 Springer Science+Business Media New York
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Dringenberg, C., Apenberg, S., Andrassy, K. (1993). P-ANCA with Myeloperoxidase Antibodies and C-ANCA with Proteinase 3 Antibodies Define a Different Vasculitis Entity in Patients with Renal Involvement. In: Gross, W.L. (eds) ANCA-Associated Vasculitides. Advances in Experimental Medicine and Biology, vol 336. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9182-2_79
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DOI: https://doi.org/10.1007/978-1-4757-9182-2_79
Publisher Name: Springer, Boston, MA
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