Abstract
Primary infection with Epstein-Barr virus (EBV) can manifest as infectious mononucleosis (= mononucleosis infectiosa, morbus Pfeiffer, kissing disease, glandular fever) and can present with fever, pharyngitis, tonsillitis, lymphadenopathy, malaise, headache, myalgia, spleno- and hepatomegaly, rash, and leucocytosis. During childhood an EBV primary infection is mostly a mild or asymptomatic event, but even in adults severe complications are rarely observed. In the course of primary infection B-lymphocytes as well as oropharyngeal and probably also nasopharyngeal and salivary epithelial cells will be infected, and virus may persist in such cells for the entire life of the individual. Approximately 90% of the human population is infected and is thus capable of transmitting the virus for life. In general, the transmission does not occur by flighty contacts, but needs a close connexion of oral surfaces, e. g. during kissing (for reviews see Cheeseman, 1988 and Sumaya, 1989).
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References
Baboonian, C., Halliday, D., Venables, P. J. W., Pawlowski, T., Millman, G. and Maini, R. N. (1989). Rheumatol. Intl. 9, 161–166.
Birkenfeld, P., Haratz, N., Klein, G. and Sulitzeanu, D. (1990). Clin. Immunol. Immunopathol. 54, 14–25.
Cheeseman, S. H. (1988). Sem. Hematol. 25, 261–268.
Dillner, J. and Kallin, B. (1988). In Advances in Cancer Research Vol. 50 (G. Klein and S. Weinhouse, eds.), pp. 95–158, Academic Press, San Diego.
Faerber, I., Wutzler, P., Wohlrabe, P., Wolf, H., Hinderer, W. and Sonneborn, H.-H. (1993). J. Virol. Method. 42, 301–308.
Fox, R. I., Scott, S., Houghten, R., Whalley, A., Geltofsky, J., Vaughan, J. and Smith, R. (1987). J. Clin. Lab. Anal. 1, 140–145.
Geltofsky, J. E., Smith, R. S., Whalley, A. and Rhodes, G. (1987). J. Clin. Lab. Anal. 1, 153–162.
Gorgievski-Hrisoho, M., Hinderer, W., Nebel-Schickel, H., Horn, J., Vornhagen, R., Sonneborn, H.-H., Wolf, H. and Siegl, G. (1990). J. Clin. Microbiol. 28, 2305–2311.
Henle, G., Henle, W. and Klein, G. (1971). Intl. J. Cancer 8, 272–282.
Henle, G., Lenette, E. T., Alspaugh, M. A. and Henle, W. (1979). tl 36, 415–422.
Henle, W., Henle, G. andersson, J., Ernberg, J., Klein, G., Horwitz, C. A., Marklund, G., Rymo, L., Wellinder, C. and Straus, S. E. (1987). Proc. Natl. Acad. Sci. USA 84, 570–574.
Henle, W., Henle, G. and Horwitz, C. A. (1974). Hum. Pathol. 5, 551–556.
Hinderer, W., Nebel-Schickel, H., Sonneborn, H.-H., Motz, M., Kühbeck, R. and Wolf, H. (1988). J. Exptl. Cancer Res. 7, 132.
Hinderer, W., Nebel-Schickel, H., Horn, J., Vornhagen, R., Sonneborn, H.-H., Gorgievski-Hrisoho, M., Siegl, G., Faerber, I., Wutzler, P. and Wolf, H. (1991). In Epstein-Barr Virus and Human Disease 1990 (D. V. Ablashi, A. T. Huang, J. S. Pagano, G. R. Pearson and C. S. Yang, eds.), pp. 123–125, Humana Press, Clifton.
Linde, A., Kallin, B., Dillner, J. Andersson, J., Jägdahl, L., Lindvall, A. and Wahren, B. (1990)4. Infect. Dis. 161, 903–909.
Middeldorp, J. M. and Meloen, R. H. (1988). J. Virol. Method. 21, 147–159.
Motz, M., Fan, J., Seibl, R., Jilg, W. and Wolf, H. (1986). Gene 42, 303–312.
Pearson, G. R. (1988). J. Virol. Method. 21, 97–104.
Pearson, G. R. and Luka, J. (1986). In The Epstein-Barr Virus: Recent Advances (M. A. Epstein and B. G. Achong, eds.), pp. 48–74, W. Heinemann, London.
Reedman, B. M. and Klein, G. (1973). Intl. J. Cancer 11, 499–520.
Sumaya, C. V. (1989). J. Clin. Immunoassay 12, 168–174.
Van Grunsven, W. M. J., Van Heerde, E. C., De Haard, H. J. W.,Spaan, W. J. M. and Middeldorp, J. M. (1993a). J. Virol. 67, 3908–3916.
Van Grunsven, W. M. J., Nabbe, A. and Middeldorp, J. M. (1993b). J. Med. Virol. 40, 161–169.
Wolf, H., Motz, M., Kühbeck, R., Seibl, R., Bayliss, G. J., Modrow, S. and Fan, J. (1985). In Developements in Medical Virology Vol. 1: Epstein-Barr Virus and Associated Diseases (P. H. Levine, D. V. Ablashi and G. R. Pearson, eds.), pp. 485–494, M. Nijhoff Publishing, Boston.
zur Hausen, H., Schulte-Holthausen, H., Klein, G., Henle, W., Henle, G., Clifford, P. and Santesson, L. (1970). Nature 288, 1056–1058.
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Hinderer, W., Siegl, G. (1994). Application of Recombinant Antigens for the Diagnosis of Acute Epstein-Barr Virus Infection. In: Kurstak, E., Marusyk, R.G., Murphy, F.A., Van Regenmortel, M.H.V. (eds) Applied Virology Research. Applied Virology Research, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9265-2_9
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