Abstract
It has been reasoned that bacterial β-lactamases must have a “normal” physiological function, apart from inactivating β-lactam antibiotics, probably connected to the metabolism of cell wall peptidoglycan (Abraham and Chain, 1940; Saz and Lowery, 1979). In the same context, evidence has been brought forward which points to an essential role of peptidoglycan metabolism in the induced synthesis of β-lactamase in Gram-positive and Gram-negative bacteria (Collins, 1979; Tuomanen et al., 1991).
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Martin, H.H., Schmidt, H. (1993). Disturbance of Peptidoglycan Synthesis by Glycine and D-Methionine Creates a Signal for the ampG-Mediated Induction of AmpC-β-Lactamase in Escherichia coli . In: de Pedro, M.A., Höltje, JV., Löffelhardt, W. (eds) Bacterial Growth and Lysis. Federation of European Microbiological Societies Symposium Series, vol 65. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9359-8_40
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DOI: https://doi.org/10.1007/978-1-4757-9359-8_40
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