Abstract
An emerging thought in sialobiology holds that lessened sialylation of gangliosides by whatever means leads in the growing neuron to a quick breakdown of neurital processes followed by neuronal loss of function. This chapter will take a brief look at findings stemming from work around that idea now in full swing in the author’s laboratory.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bergeron, J.J.M., Brenner, M. B., Thomas, D. Y., and Williams, D. B., 1994, Calnexin: A membrane-bound chaperone of the endoplasmic reticulum, Trends Biochem. Sci. 19: 124–128.
Carafoli, E., 1987, Intracellular calcium homeostasis, Annu. Rev. Biochem. 56: 395–443.
Chan, K.-F.J., 1987, Ganglioside-modulated protein phosphorylation, J. Biol. Chem. 262: 5248–5255.
Choi, D. W., 1987, Ionic dependence of glutamate neurotoxicity, J. Neurosci. 7: 369–379.
Coyle, J. T., and Schwarcz, R., 1976, Lesion of striatal neurons with kainic acid provides a model for Huntington’s chorea, Nature 263: 244–246.
Dow, K., and Riopelle, R. J., 1985, Ethanol neurotoxicity: Effects on neurite formation and neurotrophic factor production in vitro, Science 228: 591–593.
Feizi, T., 1994, Evidence for carbohydrate-mediated interactions between the neural cell-adhesionmolecules NCAM and Ll, Trends Biochem. Sci. 19: 233–234.
Greenamyre, J. T., and Young, A. B., 1989, Excitatory amino acids and Alzheimer’s disease, Neurobiol. Aging 10: 593–602.
Hogan, M. V., Saito, M., and Rosenberg, A., 1988, Influence of monensin on ganglioside anabolism and neunte stability in cultured chick neurons, J. Neurosci. Res. 20: 390–394.
Igarishi, M., Waki, H., Saito, S., Komiya, Y., and Ando, S., 1994, Characteristics of gangliosides including 0-acetylated species in growth cone membranes at several developmental stages in rat forebrain, Dell. Brain Res. 78: 17–24.
Mattson, M. P., 1990, Antigenic changes similar to those seen in neurofibrillary tangles are elicited by glutamate and Ca2+ influx in cultured hippocampal neurons, Neuron 4: 105–117.
Mattson, M. P., Rychlik, B., Chu, C., and Chrystakos, S., 1991, Evidence for calcium-reducing and excitoprotective roles for the calcium-binding protein calbindin-D28K in cultured hippocampal neurons, Neuron 6: 41–51.
Miller, M. W., 1993, Migration of cortical neurons is altered by gestational exposure to ethanol, Alcohol Clin. Exp. Res. 17: 304–314.
Rosenberg, A., and Noble, E. P., 1992, Complex higher gangliosides made in Golgi spur outgrowth of neurites in chick brain neurons, Brain Dysfunct. 5: 184–191.
Rosenberg, A., and Noble, E. P., 1993, Inhibition of neuritogenic ganglioside biosynthesis in chick brain neurons by calcium ionophore A23187, Biochem. Biophys. Res. Commun. 190: 522–528.
Rosenberg, A., and Noble, E. P., 1994, Ethanol attenuation of ganglioside sialylation and neuritogenesis, Alcohol 11: 565–569.
Rosenberg, A., Sauer, A., Noble, E. P., Gross, H.-J., Chang, R., and Brossmer, R., 1992, Developmental patterns of ganglioside sialylation coincident with neuritogensis in cultured embryonic chick brain neurons, J. Biol. Chem. 267: 10607–10612.
Rothman, S. M., and Olney, J. W., 1986, Glutamate and the pathology of hypoxic-ischemic brain damage, Ann. Neurol. 19: 105–111.
Van Echten, G., and Sandhof, K., 1989, Modulation of ganglioside biosynthesis in primary cultured neurons, J. Neurochem. 52: 207–214.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer Science+Business Media New York
About this chapter
Cite this chapter
Rosenberg, A. (1995). Neurite Loss Caused by Ganglioside Undersialylation. In: Rosenberg, A. (eds) Biology of the Sialic Acids. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9504-2_11
Download citation
DOI: https://doi.org/10.1007/978-1-4757-9504-2_11
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-9506-6
Online ISBN: 978-1-4757-9504-2
eBook Packages: Springer Book Archive