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Halogenated Benzamides as Ligands for Cerebral Dopamine Receptors

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Chemists’ Views of Imaging Centers

Abstract

In the past several years our group has synthesized a series of high affinity iodine-123 and fluorine-18 labeled substituted benzamide ligands for SPECT and PET visualization of the dopamine D-2 receptors in brain regions with low receptor density outside the striatum. Radioiodination and radiofluorination in high yield and high specific activity was achieved by using the tributyltin precursor and nucleophilic displacement of the toluensulfonyl ester precursor, respectively.

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Author information

Authors and Affiliations

  1. Department of Radiology, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA

    Ronald G. Manning, N. Scott Mason, Tomas de Paulis & Robert M. Kessler

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  1. Ronald G. Manning
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  2. N. Scott Mason
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  3. Tomas de Paulis
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  4. Robert M. Kessler
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Editors and Affiliations

  1. Health Science Center, The University of Texas, Houston, Texas, USA

    Ali M. Emran

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© 1995 Springer Science+Business Media New York

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Manning, R.G., Mason, N.S., de Paulis, T., Kessler, R.M. (1995). Halogenated Benzamides as Ligands for Cerebral Dopamine Receptors. In: Emran, A.M. (eds) Chemists’ Views of Imaging Centers. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9670-4_28

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  • DOI: https://doi.org/10.1007/978-1-4757-9670-4_28

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9672-8

  • Online ISBN: 978-1-4757-9670-4

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