Abstract
It has been well established that altitude acclimatization not only induces augmented ventilatory response to hypoxia3 but also deteriorative effect on ventilation1. The latter is well known as hypoxic ventilatory depression (HVD) for patients with chronic mountain sickness2, 4. As is presented in our other report in this proceedings8, in early acclimatizing period we should take such HVD into account for comprehending serial change of ventilatory response. HVD in humans has been observed and studied by many scientists. In addition to biphasic ventilatory response to sustained mild hypoxia5, paradoxical hyperpnea in response to oxygen administration in patients with chronic mountain sickness is also another important topics in current studies7, 10. If a subject developed hyperpnea by oxygen breathing, it can be considered to be relieved from hypoxic ventilatory depression.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
P.A. Easton, L.J. Slykerman, N.R. Anthonisen, Ventilatory response to sustained hypoxia in normal adults. J. Appl. Physiol. 61: 906–911, (1986).
P.H. Hackett, et. al. Control of breathing in Sherpas at low and high altitude. J. Appl. Physiol. 49(3): 374–379, (1980).
Y. Honda, N. Hata, Y. Sakakibara, et al. Central hypoxic-hypercapnic interaction in mild hypoxia in man. Pfluegers. Arch. 391: 289, (1981).
A. Hurtado, Animals in high altitudes: resident man. In: Handbook Physiology. Adaptation of Environment. Washington D.C.:Am. Physiol. Soc., p843–860, (1964).
S. Kagawa, et al. No effect of naloxone on hypoxia-induced ventilatory depression in adults. J. Appl. Physiol. 52: 1030–1034, (1982).
T. Kobayashi, S. Masuyama, A. Masuda, Y. Sakakibara, M. Hayano, A. Kojima, K. Hasako, T. Kuriyama and Y. Honda, Control of Breathing and Metabolism in Tibetans. in: “High-Altitude Medical Science” G. Ueda et al., eds. Shinshu Univ., Matsumoto (1992)
Lahiri, S., J.S. Milledge et al. Respiration and heart rate of Sherpa highlanders during exercise. J. Appl. Physiol. 23:545–554, (1967).
A. Masuda, S. Masuyama, T. Kobayashi, Y. Sakakibara, M. Hayano, K. Hasako, A. Kojima, T. Kuriyama and Y. Honda, Serial Changes in Acute Hypoxic and Hypercapnic Ventilatory Responses during High Altitude Acclimatization. in: “Control of Breathing and Its Modeling Perspective” Y. Honda et al., eds. Plenum, New York (1992)
S. Masuyama, K. Hasako, A. Kojima, T. Kuriyama, Y. Honda, Do Nepalese Sherpas Maintain High Hypoxic Ventilatory Drive? Jap. J. Mount. Med. vol.10: 81–90, (1990).
S.C. Severinghaus, C.R. Bainton, and A. Careln, Respiratory insensitivity to hypoxia in chronically hypoxic man. Respir. Physiol., 1: 308–334, (1966).
S. Sun, et al. Higher ventilatory drives in Tibetan than male residents of Lhasa (3685M). Am. Rev. Respir. Dis. 137: A140, (1988).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer Science+Business Media New York
About this chapter
Cite this chapter
Masuyama, S. et al. (1992). Altitude Acclimatization and Hypoxic Ventilatory Depression: Lowlanders and Highlanders. In: Honda, Y., Miyamoto, Y., Konno, K., Widdicombe, J.G. (eds) Control of Breathing and Its Modeling Perspective. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9847-0_77
Download citation
DOI: https://doi.org/10.1007/978-1-4757-9847-0_77
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-9849-4
Online ISBN: 978-1-4757-9847-0
eBook Packages: Springer Book Archive