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Parvovirus B19 Infection

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Viral Infections of Humans

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Abstract

The human parvovirus B19 (B19) was discovered in 1975. Parvovirus B19 is the only known human pathogenic parvovirus. Unlike many virus infections, the disease manifestation of infection with parvovirus B19 varies widely with the immunologic and hematologic status of the host. In individuals with underlying hemolytic disorders, B19 is the primary cause of aplastic crisis. In immunocompromised patients, persistent B19 viremia may develop that manifests as pure red cell aplasia and chronic anemia, and in the fetus, where the immune response is immature infection, it may lead to fetal death in utero or hydrops fetalis. The major disease manifestation in normal, immunocompetent individuals is erythema infectiosum (EI), also called fifth disease or “slapped-cheek” disease. Generally this is an innocuous rash disease of childhood, but in adults it may also be associated with an acute symmetrical polyarthropathy, which can mimic acute rheumatoid arthritis.

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  1. Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland, 20892-1652, USA

    Kevin E. Brown & Neal S. Young

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  1. Kevin E. Brown
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  1. Department of Epidemiology and Public Health, Yale University School of Medicine, 06510, New Haven, Connecticut, USA

    Alfred S. Evans

  2. Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, 35294-0008, Birmingham, Alabama, USA

    Richard A. Kaslow

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Brown, K.E., Young, N.S. (1997). Parvovirus B19 Infection. In: Evans, A.S., Kaslow, R.A. (eds) Viral Infections of Humans. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0036-4_20

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  • DOI: https://doi.org/10.1007/978-1-4899-0036-4_20

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