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Speculations on the Molecular Mechanisms Underlying Dopamine Agonist-Induced Dyskinesias in Parkinsonism

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The Basal Ganglia V

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 47))

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Abstract

Long-term treatment of Parkinson’s disease with dopamine-replacing agents fre-quently results in the appearance of debilitating dyskinetic side-effects. The neural mechanisms underlying these so-called dopamine agonist-induced dyskinesias remain unclear. This chapter summarises some of our recent molecular data, obtained in the 6-hydroxydopaminelesioned rat model of Parkinson’s disease, that suggest a role for both enkephalin and dynorphin in the generation of the symptoms of dopamine agonist-induced dyskinesias.

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Authors and Affiliations

  1. Division of Neuroscience, School of Biological Sciences, University of Manchester, Stopford Building, Oxford Road, M13 9PT, UK

    Brian Henry, Alan R. Crossman & Jonathan M. Brotchie

  2. Pharmacology Group, King’s College London, Manresa Road, London, SW3 6LX, UK

    Susan Duty

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  1. Susan Duty
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  2. Brian Henry
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  3. Alan R. Crossman
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  4. Jonathan M. Brotchie
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Editors and Affiliations

  1. Gunma University, Maebashi, Gunma, Japan

    Chihiro Ohye

  2. Osaka University, Toyonaka, Osaka, Japan

    Minoru Kimura

  3. The University of Melbourne, Parkville, Victoria, Australia

    John S. McKenzie

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© 1996 Springer Science+Business Media New York

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Duty, S., Henry, B., Crossman, A.R., Brotchie, J.M. (1996). Speculations on the Molecular Mechanisms Underlying Dopamine Agonist-Induced Dyskinesias in Parkinsonism. In: Ohye, C., Kimura, M., McKenzie, J.S. (eds) The Basal Ganglia V. Advances in Behavioral Biology, vol 47. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0194-1_41

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  • DOI: https://doi.org/10.1007/978-1-4899-0194-1_41

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0196-5

  • Online ISBN: 978-1-4899-0194-1

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