Abstract
The brain extracellular fluid constitutes the microenvironment on which specific nervous tissue functions are highly dependent (27). Thus its composition should be strictly maintained. Cellular processes of secretion and uptake as well as the homeostatic mechanisms of blood and cerebrospinal fluid (CSF) probably contribute to buffering changes in the extracellular fluid composition evoked by cellular activities. The extracellular space is also the main medium of communication between nerve cells through which their chemical signals are transmitted. For these reasons, many studies have been performed to determine the “in vivo” extracellular fluid concentrations of neuroactive substances such as catecholamines, their metabolites (5) and ions (9), during basal and altered cellular activities, since such information will improve significantly our understanding of CNS physiology.
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del Rio, R.M., Herranz, A.S., Solis, J.M., Herreras, O., Lerma, J. (1987). Basal Concentration and Evoked Changes of Extracellular Taurine in the Rat Hippocampus in Vivo. In: Huxtable, R.J., Franconi, F., Giotti, A. (eds) The Biology of Taurine. Advances in Experimental Medicine and Biology, vol 217. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0405-8_31
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DOI: https://doi.org/10.1007/978-1-4899-0405-8_31
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