Abstract
Several biologically active compounds are capable of forming intermolecular non-covalent complexes with deoxyribonucleic acid (DNA) under free energy changes of less than 40 kJ/mol (approximately 10 kcal/mol)[1–4]. These complexes are in the first place investigated on isolated DNA. There is, however, indication that they are also present in biological systems, where the nucleic acids exist in their natural state[5,6].
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
A. Blake and A. R. Peacocke, The interactions of aminoacridines with nucleic acids, Biopolymers 6: 1225 (1968).
G. Löber, On the complex formation of acridine dyes with DNA- IV. The equilibrium constants of substituted proflavine and acridine orange derivatives, Photochem.Photobiol. 8: 23 (1968).
G. Löber and G. Achtert, On the complex formation of acridine dyes with DNA-VII. Dependence of the binding on the dye structure, Biopolymers 8: 595 (1969).
G. Löber, Zur Komplexbindung von Farbstoffen mit Desoxyribonucleinsäuren, Z.Chem. 9: 252 (1969).
G. Löber, W. Fleck, H.-E. Jacob, and K. Rost, Beziehungen zwischen der Komplexbindung mit DNS und einigen biologischen Wirkungen von Acridinfarbstoffen, in Wirkungsmechanismen von Fungiziden, Antibiotika und Cytostatika, H. Lyr and W. Rawald, eds., Akademie-Verlag, Berlin (1970) p. 39.
G. Löber, Acridine - ihre physikochemische und biochemische Bedeutung. Eine Betrachtung anläßlich der Entdeckung des Acridins vor 100 Jahren. Teil II. Z.Chem. 11: 135 (1971).
G. Löber, and L. Kittler, Selected topics in photochemistry of nucleic acids, Recent results and perspectives, Photochem.Photobiol. 25: 215 (1977).
G. Löber, The fluorescence of dye-nucleic acid complexes. J.Luminescence 22: 221 (1981).
Z. Balcarovä, V. Kleinwächter, J. Koudelka, G. Löber, K. E. Reinert, L. P. G. Wakelin, and M. J. Waring, Interaction of phenosafranine with nucleic acids and model polyphosphates. II. Characterization of phenosafranine binding to DNA. Biophys.Chem. 8: 27 (1978).
G. Löber, L. Kittler, R. Klarner, Z. Hradecna, V. Kleinwächter, Z. Balcarovâ, M. Skalka, J. Koudelka, E. Smdkal, L. Popa and V. Beensen, DNA-drug interactions (A minireview). Studia biophysica 88: 1 (1982).
G. Löber, H. Schütz, and V. Kleinwächter, Effect of organic solvents on the properties of the complexes of DNA with proflavine and similar compounds. Biopolymers 11: 2439 (1972).
T. T. Herskovits, Nonaqueous solution of DNA: factors determining the stability of the helical configuration in solution. Arch.biochem.Biophys. 97: 474 (1962).
V. Kleinwchter and J. Koudelka, Thermal denaturation of deoxyribonucleic acid acridine orange complex. Biochim. Biophys.Acta 91:539 (1964).
G. Löber, R. Klarner, E. Smékal, T. Räim, Z. Balcarovâ, J. Koudelka, and V. Kleinwächter, Spectroscopic investigations on the interaction of the anthracycline antibiotic violamycin BI with deoxyribonucleic acid, Int.J.Biochem. 15: 663–673 (1983).
U. Katenkamp, E. Stutter, I. Petri, F. A. Gollmick, and H. Berg, Interaction of authracyline antibiotics with biopolymers. VIII. Binding parameters of aclacinomycin A to DNA. J.Antibiotics 36: 1222–1227 (1983).
G. Löber, V. Kleinwächter, J. Koudelka, and E. Smékal, On spectral properties of type I complexes of dyes with deoxyribonucleic acid and human serum albumin. Studia biophysica 45: 91 (1974).
H. Lang and G. Löber, Die Lösungsmittelabhängigkeit der Elektronenspektren von kationischen Acridinfarbstoffen, Ber.Bunsenges.physik.Chem. 73: 710 (1969).
G. Löber, and V. Kleinwächter, Effect of organic solvents on the properties of the complex polyphosphate-acridine orange (preliminary note), Studia biophysica 33: 73 (1972).
G. Löber, V. Kleinwächter, and H. Berg, Effect of organic solvents on the properties of the complexes of a polyphosphate with acridines, Studia biophysica 35: 29 (1973).
G. Löber, V. Kleinwächter, and J. Koudelka, Staining of chromosomes with basic dyes, Studia biophysica 55: 49 (1976).
G. Löber, V. Kleinwächter, J. Koudelka, Z. Balcarovâ, J. Filkuka, P. Krejci, P. Döbel, V. Beensen, and R. Rieger, Molecular and spectroscopic aspects of chromosome banding, Biol.Zbl. 95: 169 (1976).
G. Löber, V. Beensen, Ch. Zimmer, and H. Hanschmann, Changes of quinacrine staining of human chromosomes by the competitive binding of A.T and G.C-specific substances, Studia biophysica 69: 237 (1978).
G. Löber, On the spectroscopic basis of acridine-induced fluorescence banding patterns in chromosomes. Studia bio physica 48: 109 (1975).
C. J. Seliskar and L. Brand, Electronic spectra of 1 aminonaphthalene-6-sulfonate and related molecules, J.Am. Chem.Soc. 93: 5414 (1971).
R. D. G. McKay, The mechanism of G- and C-banding in mammalian metaphase chromosomes. Chromosome (Berlin) 44: 1 (1973).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Springer Science+Business Media New York
About this chapter
Cite this chapter
Löber, G., Klarner, R. (1985). Water and DNA-Drug Interaction. In: Pullman, A., Vasilescu, V., Packer, L. (eds) Water and Ions in Biological Systems. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0424-9_74
Download citation
DOI: https://doi.org/10.1007/978-1-4899-0424-9_74
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-0426-3
Online ISBN: 978-1-4899-0424-9
eBook Packages: Springer Book Archive