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Endothelial Cell Response to Normal and Abnormal Stimuli

Modulation, Dysfunction, Injury; Adaptation, Repair, Death

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Endothelial Cell Dysfunctions

Abstract

Normal eukaryotic cells interact continuously and subtly with their surrounding milieu; variations in the nature, duration, and intensity of the extracellular stimuli generate a bidirectional interplay between the two. By virtue of their programmed genotype and the expressed metabolic, functional, and structural phenotype, cells are endowed with a finite capacity to adapt. In a homeostatic steady state, cells are able to handle normal physiologic demands. If the limits of their adaptive capacity are exceeded, as the result of excessive physiologic stimuli or pathologic stresses, the steady state can be altered. By their struggle to adapt, cells try to escape damage and premature death.

What we do not understand, we do not possess.

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Authors and Affiliations

  1. Institute of Cellular Biology and Pathology, Bucharest, 79691, Romania

    Maya Simionescu

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  1. Maya Simionescu
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  1. Institute of Cellular Biology and Pathology, Bucharest, Romania

    Nicolae Simionescu  & Maya Simionescu  & 

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Simionescu, M. (1992). Endothelial Cell Response to Normal and Abnormal Stimuli. In: Simionescu, N., Simionescu, M. (eds) Endothelial Cell Dysfunctions. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0721-9_1

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  • DOI: https://doi.org/10.1007/978-1-4899-0721-9_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0723-3

  • Online ISBN: 978-1-4899-0721-9

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