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Production of Growth Factors by Normal Human Mammary Cells in Culture

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Human Lactation 3

Abstract

Recent evidence from several laboratories has demonstrated that human breast cancer cell lines produce a variety of polypeptide growth factors, including platelet derived growth factor (PDGF), insulin like growth factor (IGFI), transforming growth factors alpha and beta (TGFα and TGFβ), mammary-derived growth factor I (MDGFI), mammary-derived growth factor II (MDGFII), gastrin releasing peptide (GRP), human mammary tumor growth factor (h.MTGF) and epidermal growth factor (EGF). It has been assumed that production of the factors was a pathological phenomenon, one accompanying neoplastic transformation. However, we and others have shown that most of these are normal components of milk. Consequently, we postulated that the tumor cell-derived factors might be normal glandular secretory products.

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Author information

Authors and Affiliations

  1. National Cancer Institute, Bethesda, Maryland, 20892, USA

    William R. Kidwell, David S. Salomon & S. Mohanam

  2. Chiron Labs, Emeryville, California, 94608, USA

    Graeme I. Bell

Authors
  1. William R. Kidwell
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  2. David S. Salomon
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  3. S. Mohanam
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  4. Graeme I. Bell
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Editor information

Editors and Affiliations

  1. University of Texas Medical Branch, Galveston, Texas, USA

    Armond S. Goldman

  2. McMaster University, Hamilton, Ontario, Canada

    Stephanie A. Atkinson

  3. University of Göteborg, Göteborg, Sweden

    Lars Å. Hanson

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© 1987 Springer Science+Business Media New York

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Kidwell, W.R., Salomon, D.S., Mohanam, S., Bell, G.I. (1987). Production of Growth Factors by Normal Human Mammary Cells in Culture. In: Goldman, A.S., Atkinson, S.A., Hanson, L.Å. (eds) Human Lactation 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0837-7_25

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  • DOI: https://doi.org/10.1007/978-1-4899-0837-7_25

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0839-1

  • Online ISBN: 978-1-4899-0837-7

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