Abstract
Adrenodoxin belongs to the family of /2Fe-2S/ type ferredoxins being widely distributed in bacteria, plants and animals. Although adrenodoxin is a small (~14 kDa) and soluble protein, its three-dimensional structure has not been elucidated as yet. It functions as an electron carrier from the FAD-containing NADPH-dependent ferredoxin reductase to the cytochromes P450scc (CYP11A1), which catalyzes the side-chain cleavage of cholesterol, the initial step in adrenal steroidogenesis, and P45011β (CYP11B1), being involved in the formation of cortisol and aldosterone (Fig. 1).
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Bernhardt, R., Kraft, R., Uhlmann, H., Beckert, V. (1995). Investigation of Protein-Protein Interactions in Mitochondrial Steroid Hydroxylase Systems Using Site-Directed Mutagenesis. In: Atassi, M.Z., Appella, E. (eds) Methods in Protein Structure Analysis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1031-8_25
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DOI: https://doi.org/10.1007/978-1-4899-1031-8_25
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