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Association of BK and JC Human Polyomaviruses and SV40 with Human Tumors

  • Chapter
DNA Tumor Viruses

Part of the book series: Infectious Agents and Pathogenesis ((IAPA))

Abstract

The human polyomaviruses BK (BKV) and JC (JCV) are ubiquitous in human populations and have a worldwide distribution.(1) They are oncogenic in rodents and monkeys and transform cells in vitro to a neoplastic phenotype. For all these reasons, BKV and JCV have been considered possible candidates in the etiology of human tumors. Association of BKV, but not of JCV, with human tumors has been described, although a formal proof for an etiological role of BKV in human oncogenesis is still lacking. SV40, which is not a ubiquitous human virus, has also been sporadically detected in human tumors. In this chapter, we consider their general characteristics, the natural history of infection, experimental transformation and oncogenicity by BKV and JCV, as well as the evidence linking BKV, JCV, and SV40 to human neoplasia.

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Authors and Affiliations

  1. Institute of Microbiology, School of Medicine, University of Ferrara, I-44100, Ferrara, Italy

    Paolo Monini, Laura de Lellis & Giuseppe Barbanti-Brodano

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  1. Paolo Monini
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  2. Laura de Lellis
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  3. Giuseppe Barbanti-Brodano
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Editors and Affiliations

  1. Institute of Microbiology, School of Medicine, University of Ferrara, I-44100, Ferrara, Italy

    Giuseppe Barbanti-Brodano

  2. University of Pisa, Pisa, Italy

    Mauro Bendinelli

  3. University of South Florida, Tampa, Florida, USA

    Herman Friedman

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Monini, P., de Lellis, L., Barbanti-Brodano, G. (1995). Association of BK and JC Human Polyomaviruses and SV40 with Human Tumors. In: Barbanti-Brodano, G., Bendinelli, M., Friedman, H. (eds) DNA Tumor Viruses. Infectious Agents and Pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1100-1_4

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  • DOI: https://doi.org/10.1007/978-1-4899-1100-1_4

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