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Papillomaviruses as Promoting Agents in Human Epithelial Tumors

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DNA Tumor Viruses

Part of the book series: Infectious Agents and Pathogenesis ((IAPA))

Abstract

The papillomaviruses (PVs) are a large family of DNA viruses indigenous to many, if not all, vertebrate species. The unique feature of these viruses is that they all induce primarily benign proliferations of epithelial cells in their natural hosts. Individual members of this family show a high degree of both species specificity and tissue specificity. Squamous or mucosal epithelial cells are the targets of infection. The life cycle of the virus is intimately coupled to the differentiation program of infected tissue. Conversely, expression of the early viral genes interferes with the normal pattern of keratin expression, cell cycle regulation, and terminal differentiation, which ultimately gives rise to aberrant cells. With some viral types, however, these benign proliferations progress into aggressive malignancies.

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  1. Institute of Tumor Biology—Cancer Research, University of Vienna, 1090, Vienna, Austria

    Christa Cerni & Christian Seelos

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  1. Institute of Microbiology, School of Medicine, University of Ferrara, I-44100, Ferrara, Italy

    Giuseppe Barbanti-Brodano

  2. University of Pisa, Pisa, Italy

    Mauro Bendinelli

  3. University of South Florida, Tampa, Florida, USA

    Herman Friedman

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Cerni, C., Seelos, C. (1995). Papillomaviruses as Promoting Agents in Human Epithelial Tumors. In: Barbanti-Brodano, G., Bendinelli, M., Friedman, H. (eds) DNA Tumor Viruses. Infectious Agents and Pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1100-1_8

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