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Characterization of a Cis-Regulatory Element and Trans-Acting Protein that Regulates Transcription of the Angiotensin II Type 1A Receptor Gene

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Recent Advances in Cellular and Molecular Aspects of Angiotensin Receptors

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 396))

Abstract

Angiotensin II (Ang II) has multiple physiological effects in the cardiovascular, endocrine, and nervous systems that are initiated by binding to specific receptors located on the plasma membrane (1). Two major subtypes (type 1 and type 2) of Ang II receptors have been revealed by their differential affinity for nonpeptide drugs (2). Ang II type 1a receptor (AT1a-R) cDNAs have been cloned from rat vascular smooth muscle cells (3), bovine adrenal zona glomerular cells (4) and rat kidney (5). Ang II mRNA is expressed in a variety of cells and tissues including vascular smooth muscle cells, liver, kidney and spleen, while the mRNA abundance is low in other tissues such as heart, brain, thymus and testis. AT1a-R gene expression is regulated in an ontogenic manner (6). Thus, the rat AT1a-R gene is cell-specifically and developmentally regulated.

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Authors and Affiliations

  1. Second Department of Internal Medicine, Kansai Medical University, Fumizonocho 1, Moriguchi, Osaka 570, Japan

    Satoshi Murasawa, Hiroaki Matsubara, Yasukiyo Mori, Kazuhisa Kijima, Katsuya Maruyama & Mitsuo Inada

Authors
  1. Satoshi Murasawa
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  2. Hiroaki Matsubara
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  3. Yasukiyo Mori
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  4. Kazuhisa Kijima
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  5. Katsuya Maruyama
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  6. Mitsuo Inada
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Editor information

Editors and Affiliations

  1. University of Florida, Gainesville, Florida, USA

    Mohan K. Raizada , M. Ian Phillips  & Colin Sumners ,  & 

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© 1996 Springer Science+Business Media New York

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Murasawa, S., Matsubara, H., Mori, Y., Kijima, K., Maruyama, K., Inada, M. (1996). Characterization of a Cis-Regulatory Element and Trans-Acting Protein that Regulates Transcription of the Angiotensin II Type 1A Receptor Gene. In: Raizada, M.K., Phillips, M.I., Sumners, C. (eds) Recent Advances in Cellular and Molecular Aspects of Angiotensin Receptors. Advances in Experimental Medicine and Biology, vol 396. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1376-0_1

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  • DOI: https://doi.org/10.1007/978-1-4899-1376-0_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1378-4

  • Online ISBN: 978-1-4899-1376-0

  • eBook Packages: Springer Book Archive

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