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Some Recent Advances in Leukotriene Research

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Recent Advances in Prostaglandin, Thromboxane, and Leukotriene Research

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 433))

Abstract

The leukotrienes are formed by transformation of arachidonic acid into an unstable epoxide intermediate, leukotriene A4 (LTA4), which can be converted enzymatically by hydration to LTB4, and by addition of glutathione to LTC4. This last compound is metabolized to LTD4 and LTE4 by successive elimination of a γ-glutanyl residue and glycine1, 2.

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Author information

Authors and Affiliations

  1. Department of Biochemistry and Biophysics, Division of Physiological Chemistry II, Karolinska Institutet, S-171 77, Stockholm, Sweden

    Bengt Samuelsson

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  1. Bengt Samuelsson
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Editor information

Editors and Affiliations

  1. Wilhelm Auerswald Atherosclerosis Research Group Vienna, University of Vienna, Vienna, Austria

    Helmut Sinzinger

  2. Karolinska Institutet, Stockholm, Sweden

    Bengt Samuelsson

  3. The William Harvey Research Institute, London, England

    John R. Vane

  4. University of Milan, Milan, Italy

    Rodolfo Paoletti

  5. Georgetown University Medical Center, Washington, DC, USA

    Peter Ramwell

  6. University of Medicine and Dentistry of New Jersey, Stratford, New Jersey, USA

    Patrick Y.-K. Wong

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Samuelsson, B. (1997). Some Recent Advances in Leukotriene Research. In: Sinzinger, H., Samuelsson, B., Vane, J.R., Paoletti, R., Ramwell, P., Wong, P.YK. (eds) Recent Advances in Prostaglandin, Thromboxane, and Leukotriene Research. Advances in Experimental Medicine and Biology, vol 433. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1810-9_1

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  • DOI: https://doi.org/10.1007/978-1-4899-1810-9_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1812-3

  • Online ISBN: 978-1-4899-1810-9

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