Abstract
In recent years several studies have examined whether eicosanoids might facilitate neurotransmission in pain pathways. Discrepancies between the doses of some non-steroidal antiinflammatory drugs (NSAIDs) required to produce antiinflammatory and analgesic effects suggest that the analgesic actions may arise through a central action of NSAIDs (McCormack and Urquart, 1995). Evidence supporting this hypothesis has come from behavioural experiments which have shown that intrathecally applied NSAIDs reduce pain-related behaviour in the rat formalin model of inflammation (Malmberg and Yaksh, 1992). Furthermore, NSAIDs applied intravenously reduce the responses of rat spinal cord neurones, rendered hyperexcitable by an acute arthritic lesion, to innocuous and noxious stimuli applied to the inflamed knee (Neugebauer et al., 1995).
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Grubb, B.D., Willingale, H.L., Gardiner, N.J., Giblett, S. (1997). Functional Consequences of the Identification and Localisation of Cyclooxygenase Isoforms in Dorsal Horn of Rat Spinal Cord. In: Sinzinger, H., Samuelsson, B., Vane, J.R., Paoletti, R., Ramwell, P., Wong, P.YK. (eds) Recent Advances in Prostaglandin, Thromboxane, and Leukotriene Research. Advances in Experimental Medicine and Biology, vol 433. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1810-9_44
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DOI: https://doi.org/10.1007/978-1-4899-1810-9_44
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