Abstract
Interferon (IFN)-α is now widely used in the treatment of a number of specific neoplasms, such as hairy cell leukemia and Kaposi’s sarcoma (1,2). However the therapeutic effects of IFNs are still rather limited and the success in the treatment of other cancers has not been great. One possible approach to improving the efficacy of IFN treatment is to combine it with the use of chemotherapeutic agents, such as purine and pyrimidine analogs. Preliminary data indicates that a combination of 5-flurouracil (5-FU) and IFN-α is clinically relevant (3–9), and this combination has been used in the treatment of colon cancer and renal carcinoma with some success (10–12). 2-chlorodeoxyadenosine (2-CdA) was reported recently to be an effective agent in the treatment of hairy cell leukemia, non-Hodgkin lymphoma and chronic lymphocytic leukemia patients (13,14). However, there have been no reports of combining this drug with IFN.
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Reiter, Z., Ozes, O.N., Tomson, S., Blatt, L.M., Taylor, M.W. (1991). A Dual Anti-Tumor Effect of a Combination of Interferon-α and 5-Flurouracil or 2-Chlorodeoxyadenosine on Natural Killer (NK) Cell Mediated Cytotoxicity. In: Harkness, R.A., Elion, G.B., Zöllner, N. (eds) Purine and Pyrimidine Metabolism in Man VII. Advances in Experimental Medicine and Biology, vol 309A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2638-8_15
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