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Changes Caused by Ethanol Intake on Metabolism of Hypouricemic Agents (Combination of Allopurinol and Benzbromarone)

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Purine and Pyrimidine Metabolism in Man VII

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 309A))

Abstract

Several agents have been employed for treatment of hyperuricemia. Allopurinol, an inhibitor of xanthine oxidase (1) is often used as a hypouricemic agents. Benzbromarone, which is reported to have a uricosuric effect (2), has also been employed. It has been recently reported that combination of these two drugs has been favorable in gouty patients (3).

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References

  1. Kelley WN, Palella TD: Gout and other disorders of purine metabolism. in Braunwaid E, Isselbacher KJ, Petersdorf RG, et al (ed): Harrison’s principles of internal medicine (eleventh ed). New York, McGraw-Hill, 1987, pp 1623-1632

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  2. Zollner N, Griebsch A, Fink JK: The effect of benzbromarone on serum uric acid level and uric acid excretion in gouty persons. Dtsch Med Wochenschr 95: 2405–2412, 1970

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  4. Kaneko K, Fujimori S, Ishizuka I, et al: Effect of ethanol on metabolism of the hypouricemic agents allopurinol and benzbromarone. Clin.Chim.Acta 193:181–186, 1990.

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  5. Fujimori S, Nakayama Y, Kaneko K, et al: Contents of purine bases in alcoholic beverages. Uric Acid Research 9: 128–133, 1985

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  6. Walter-Sack I, Vries JX, Ittensohn A, et al: Benzbromarone disposition and uricosuric action; evidence for hydroxilation instead of denomination to benzarone. Klin Wochenschr 66: 160–166, 1988

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© 1991 Springer Science+Business Media New York

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Kaneko, K., Fujimori, S., Akaoka, I. (1991). Changes Caused by Ethanol Intake on Metabolism of Hypouricemic Agents (Combination of Allopurinol and Benzbromarone). In: Harkness, R.A., Elion, G.B., Zöllner, N. (eds) Purine and Pyrimidine Metabolism in Man VII. Advances in Experimental Medicine and Biology, vol 309A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2638-8_31

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  • DOI: https://doi.org/10.1007/978-1-4899-2638-8_31

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-2640-1

  • Online ISBN: 978-1-4899-2638-8

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