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Antineutrophil cytoplasmic antibodies (ANCA): current perspectives

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The Vasculitides

Abstract

The idiopathic systemic vasculitides constitute a group of disorders characterized by more or less widespread inflammation of vessel walls generally without an underlying cause or an associated condition. The idiopathic vasculitides are traditionally grouped according to the size of the vessels involved and the histopathology of the inflammatory process. Such a classification is shown in Table 4.1. A recent modification of this scheme based on a more strict application of histopathological criteria with respect to the size of the vessels involved [1], is given in Table 4.2. The definitions and classification of the vasculitides demonstrate that histopathological findings are essential for making a diagnosis of a distinct vasculitic disorder. In clinical practice, however, pathognomonic histopathological findings are hard to obtain in most patients suspected of vasculitis, even in cases where multiple biopsies have been performed [2]. For this and other reasons, classification criteria have been designed by the American College of Rheumatologists (ACR) that are mainly based on clinical signs and symptoms [3]. These criteria can be used for the classification of patients who have al.ready have been proved to have vasculitis.

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Authors
  1. C. G. M. Kallenberg
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Editor information

Editors and Affiliations

  1. Division of Rheumatology, Clinical Research Centre, Northwick Park Hospital, London, UK

    B. M. Ansell (Consultant Rheumatologist and Former Head) (Consultant Rheumatologist and Former Head)

  2. Rheumatology Department, University of Birmingham, Birmingham, UK

    P. A. Bacon (Professor of Rheumatology and Head) (Professor of Rheumatology and Head)

  3. Division of Anatomic Pathology, University of California Davis School of Medicine, Sacramento, California, USA

    J. T. Lie (Professor and Director) (Professor and Director)

  4. University of California Davis Medical Center, Sacramento, California, USA

    J. T. Lie (Professor and Director) (Professor and Director)

  5. Division of Rheumatology, Department of Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Turkey

    H. Yazici (Professor and Chief) (Professor and Chief)

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Kallenberg, C.G.M. (1996). Antineutrophil cytoplasmic antibodies (ANCA): current perspectives. In: Ansell, B.M., Bacon, P.A., Lie, J.T., Yazici, H. (eds) The Vasculitides. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2889-4_4

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  • DOI: https://doi.org/10.1007/978-1-4899-2889-4_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-412-64140-4

  • Online ISBN: 978-1-4899-2889-4

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