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Antianginal vasodilators

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Drugs for Heart Disease

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Abstract

To explain the mode of action of antianginal vasodilators (Table 4.1), requires first a reasonable hypothesis for the production of angina; secondly, an understanding of the vascular contractile mechanism and its metabolic and neurogenic control; and, thirdly, the way in which these vasodilators interact with their receptors or binding sites to produce clinical effects. On the background of such knowledge, a more rational approach to the principles (Table 4.2) and practice of the use of anti-anginal vasodilators can be formulated. This chapter will deal chiefly with the nitrates and the calcium antagonists (= calcium channel blockers); effects on the circulation as well as on the heart will be emphasized.

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Authors
  1. L. H. Opie
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  2. U. Thadani
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Editors and Affiliations

  1. Formerly Consultant Cardiologist, now retired, Department of Clinical Pharmacology, St Bartholomew’s Hospital, EC1A 7BE, London, UK

    John Hamer MD. Ph.D F.R.C.P.

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© 1987 Springer Science+Business Media Dordrecht

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Opie, L.H., Thadani, U. (1987). Antianginal vasodilators. In: Hamer, J. (eds) Drugs for Heart Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-3294-5_4

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  • DOI: https://doi.org/10.1007/978-1-4899-3294-5_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-412-26540-2

  • Online ISBN: 978-1-4899-3294-5

  • eBook Packages: Springer Book Archive

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