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Metabolic, endocrine and drug-induced myopathies

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Biopsy Pathology of Muscle

Abstract

The metabolic, endocrine and drug-induced myopathies are discussed in this chapter as a related group of disorders because, in a general sense, they share a common pathogenetic mechanism. The metabolic myopathies result from a biochemical defect in muscle metabolism itself, the endocrine myopathies from an abnormal hormonal environment, probably affecting muscle metabolism, and the drug-induced myopathies from a direct toxic effect of the drug on muscle metabolism. In some drug-induced myopathies, e.g. malignant hyperpyrexia myopathy, the drug effect is manifest only in susceptible individuals.

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References

  • Afifi, A.K., Bergman, R.A. and Harvey, J.C. (1968) Steroid myopathy: clinical, histological and cytological observations. Johns Hopkins Med. J., 123, 158–174.

    CAS  PubMed  Google Scholar 

  • Askari, A., Vignos, P. J. Jr. and Moskowitz, R.W. (1976) Steroid myopathy in connective tissue diseases. Am. J. Med., 61, 485–492.

    Article  CAS  PubMed  Google Scholar 

  • Bank, W.J., Di Mauro, S., Bonilla, E. et al. (1975) A disorder of lipid metabolism and myoglobinuria. N. Engl. J. Med., 292, 443–449.

    Article  CAS  PubMed  Google Scholar 

  • Berenberg, R.A., Pellock, J.M., Di Mauro, S. et al. (1977) Lumping or splitting? ‘Opthalmoplegia plus’ or Kearns-Sayre syndrome? Ann. Neurol., 1, 37–54.

    Article  CAS  PubMed  Google Scholar 

  • Berkovic, S.F., Carpenter, S., Evans, A. et al. (1989) Myoclonus epilepsy and ragged-red fibres (MERRF), Brain, 112, 1231–1260.

    Article  PubMed  Google Scholar 

  • Bonilla, E. and Schotland, D.L. (1970) Histochemical diagnosis of muscle phosphofructokinase deficiency. Arch. Neurol., 22, 8–12.

    Article  CAS  PubMed  Google Scholar 

  • Brunberg, J.A., McCormick, W.F. and Schochet, S.S. (1971) Type III glycogenosis. An adult with diffuse weakness and muscle wasting. Arch. Neurol., 25, 171–178.

    Article  CAS  PubMed  Google Scholar 

  • Busch, H.F.M., Koster, J.F. and van Weerden, T.W. (1979) Infantile and adult-onset acid maltase deficiency occurring in the same family. Neurology, 29, 415–416.

    Article  CAS  PubMed  Google Scholar 

  • Cornelio, F. and Di Donato, S. (1985) Myopathies due to enzyme deficiencies. J.Neurol., 232, 329–340.

    Article  CAS  PubMed  Google Scholar 

  • Denborough, M.A., Dennett, X. and Anderson, P.M. (1973) Central core disease and malignant hyperpyrexia. Br. Med. J., 1, 272–273.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Di Mauro, S. and Hartlage, P.L. (1978) Fatal infantile form of muscle Phosphorylase deficiency. Neurology, 28, 1124–1129.

    Article  Google Scholar 

  • Di Mauro, S., Arnold, S., Miranda, A. and Rowland, L.P. (1978) McArdle’s disease: the mystery of reappearing Phosphorylase activity in muscle culture — a fetal isoenzyme. Ann. Neurol., 3, 60–66.

    Article  Google Scholar 

  • Di Mauro, S., Bonilla, E., Zeviani, M. et al. (1989) Mitochondrial myopathies. J. Inherit. Metab. Dis., 10, Suppl. 1,113–128.

    Google Scholar 

  • Di Mauro, S., Hartwig, G.B., Hayes, A. et al. (1979) Debranching enzyme deficiency: neuromuscular disorders in 5 adults. Ann. Neurol., 5, 422–436.

    Article  Google Scholar 

  • Dubowitz, V. and Brooke, M.H. (1973) Muscle Biopsy — A Modern Approach, W.B. Saunders, London.

    Google Scholar 

  • Ellis, F.R. and Halsall, P. J. (1980) Malignant hyperpyrexia. Br. J. Hosp. Med., 24, 318–327.

    CAS  PubMed  Google Scholar 

  • Engel, A.G. (1966) Electron microscopic observations in thyrotoxic and corticosteroid-induced myopathies. Mayo Clin. Proc, 41, 785–796.

    CAS  PubMed  Google Scholar 

  • Engel, A.G. (1970a) Acid maltase deficiency in adults. Brain, 93, 599–606.

    Article  CAS  PubMed  Google Scholar 

  • Engel, A.G. (1970b) Evolution and content of vacuoles in primary hypokalemic periodic paralysis. Mayo Clin. Proc, 45, 774–814.

    CAS  PubMed  Google Scholar 

  • Engel, A.G. and Angelini, C. (1973) Carnitine deficiency of human muscle with associated lipid storage myopathy: a new syndrome. Science, 179, 899–902.

    Article  CAS  PubMed  Google Scholar 

  • Engel, W.K. (1971) ‘Ragged-red fibres’ in ophthalmoplegia syndromes and their differential diagnosis. In Muscle Diseases (ed. B. A. Kakulas), ICS 237, Excerpta Medica, Amsterdam, p. 28.

    Google Scholar 

  • Ferguson, I.T., Mahon, M. and Cumming, W.J.K. (1983) An adult case of Andersen’s disease: Type IV glycogenosis. J. Neurol. Sci., 60, 337–351.

    Article  CAS  PubMed  Google Scholar 

  • Godet-Guillain, J. and Fardeau, M. (1970) Hypothyroid myopathy: histological and ultrasfructural study of an atrophic form. In Muscle Diseases (eds J.N. Walton, N. Canal and S. Scarlato), ICS 199, Excerpta Medica, Amsterdam, pp. 512–515.

    Google Scholar 

  • Guze, B.H. and Baxter, L.R. (1986) Neuroleptic malignant syndrome. N. Engl. J. Med., 313, 163–166.

    Article  Google Scholar 

  • Hogan, G.R., Gutamann, L., Schmidt, R. and Gilbert, E. (1969) Pompe’s disease. Neurology, 19, 894–900.

    Article  CAS  PubMed  Google Scholar 

  • Holt, I.J., Harding, A.E. and Morgan-Hughes, J.A. (1988) Deletions of mitochondrial DNA in patients with mitochondrial myopathies. Nature, 331, 717–719.

    Article  CAS  PubMed  Google Scholar 

  • Karpati, G., Carpenter, S., Engel, A.G. et al. (1975) The syndrome of systemic carnitine deficiency . Neurology, 25, 16–24.

    Article  CAS  PubMed  Google Scholar 

  • Karpati, G., Carpenter, S., Eisen, A. et al. (1977) The adult form of acid maltase (a1 : 4 glucosidase) deficiency. Ann. Neurol., 1, 276–280.

    Article  CAS  PubMed  Google Scholar 

  • Lombes, A., Bonilla, E. and Di Mauro, S. (1989) Mitochondrial encephalo-myopathies. Rev. Neurol., 145, 671–689.

    CAS  PubMed  Google Scholar 

  • McArdle, B. (1951) Myopathy due to a defect in muscle glycogen breakdown. Clin. Sci., 10, 13–33.

    CAS  Google Scholar 

  • McKeran, R.O., Slavin, G., Ward, P. et al. (1980) Hypothyroid myopathy: a clinical and pathological study. J. Pathol., 132, 35–54.

    Article  CAS  PubMed  Google Scholar 

  • McMaster, K.R., Powers, J.M., Hennigar, G.R. et al (1979) Nervous system involvement in Type IV glycogenosis. Arch. Pathol. Lab. Med., 103, 105–111.

    CAS  PubMed  Google Scholar 

  • Markowitz, H. and Wobig, G.H. (1977) Quantitative method for estimating myoglobin in urine. Clin. Chem., 23, 1689–1693.

    CAS  PubMed  Google Scholar 

  • Martin, D.T. and Swash, M. (1987) Muscle pathology in the neuroleptic malignant syndrome. J. Neurol., 235, 120–121.

    Article  CAS  PubMed  Google Scholar 

  • Mastaglia, F.L. and Argov, Z. (1981) Drug-induced neuromuscular disorders in man. In Disorders of Voluntary Muscle, 4th edn (ed. J.N. Walton), Churchill Livingstone, Edinburgh, pp. 873–906.

    Google Scholar 

  • Mastaglia, F.L., Barwick, D.D. and Hall, R. (1970) Myopathy in acromegaly. Lancet, 2, 907–909.

    Article  CAS  PubMed  Google Scholar 

  • Moraes, C.T., Di Mauro, S., Zeviani, M. et al. (1989) Mitochondrial DNA deletions in progressive external ophthalmoplegia and Kearns-Sayre syndrome. N. Engl. J.Med., 320, 1293–1299.

    Article  CAS  PubMed  Google Scholar 

  • Morgan, K.G. and Bryant, S.H. (1977) The mechanism of action of dantrolene sodium. J. Pharmacol. Exp. Ther., 201, 138–141.

    CAS  PubMed  Google Scholar 

  • Morgan-Hughes, J.A. (1989) The metabolic myopathies. Curr. Opin. Neurol. Neurosurg., 2, 689–694.

    Google Scholar 

  • Nagulesparen, M., Trickey, R., Davies, M. J. and Jenkins, J.S. (1976) Muscle changes in acromegaly. Br. Med.J., 2, 914–915.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Olson, W., Engel, W.K., Walsh, G.O. and Einaugler, R. (1972) Oculo-cranio-somatic neuromuscular disease with ‘ragged-red fibres’. Histochemical and ultrastructural changes in limb muscles of a group of patients with idiopathic progressive external ophthalmoplegia. Arch. Neurol., 26, 193–211.

    Article  CAS  PubMed  Google Scholar 

  • Petty, R.K.H., Harding, A.E. and Morgan-Hughes, J.A. (1986) The clinical features of mitochondrial myopathy. Brain, 109, 915–938.

    Article  PubMed  Google Scholar 

  • Pleasure, D.E., Walsh, G.O. and Engel, W.K. (1970) Atrophy of skeletal muscles in patients with Cushing’s syndrome. Arch. Neurol., 22, 118–125.

    Article  CAS  PubMed  Google Scholar 

  • Rebouche, C. J. and Engel, A.G. (1983) Carnitine metabolism and deficiency syndromes. Mayo Clin. Proc, 58, 533–540.

    CAS  PubMed  Google Scholar 

  • Ross, B.D., Radda, G.K., Godian, D.G. et al. (1981) Examination of a case of suspected McArdle’s syndrome by 31P nuclear magnetic resonance. N. Engl. J. Med., 304, 1338–1342.

    Article  CAS  PubMed  Google Scholar 

  • Rubenstein, A.E. and Wainapel, S.F. (1977) Acute hypokalemic myopathy in alcoholism. Arch. Neurol., 34, 553–555.

    Article  CAS  PubMed  Google Scholar 

  • Schiller, H.H. and Mair, W.G.P. (1974) Ultrastructural changes of muscle in malignant hyperthermia. J. Neurol. Sci., 21, 93–100.

    Article  CAS  PubMed  Google Scholar 

  • Schott, G.D. and Wills, M.R. (1975) Myopathy in hypophosphataemic osteomalacia presenting in adult life. J. Neurol. Neurosurg. Psychiatry, 38, 297–304.

    Article  CAS  PubMed  Google Scholar 

  • Servidei, S., Shanske, S., Zeviani, M. et al. (1988) McArdle’s disease: biochemical and molecular genetic studies. Ann. Neurol., 24, 774–781.

    Article  CAS  PubMed  Google Scholar 

  • Shirabe, T., Tawara, S., Terao, A. and Araki, S. (1975) Myxoedematous polyneuropathy. J. Neurol. Neurosurg. Psychiatry, 38, 241–247.

    Article  CAS  PubMed  Google Scholar 

  • Swash, M. and Schwartz, M.S. (1983) Iatrogenic neuromuscular disorders: a review. Proc. R. Soc. Med., 76, 149–151.

    CAS  Google Scholar 

  • Swash, M., Schwartz, M.S. and Apps, M.C.P. (1985) Adult-onset acid maltase deficiency. J. Neurol. Sci., 68, 61–74.

    Article  CAS  PubMed  Google Scholar 

  • Tarui, S., Kono, N., Nasu, T. and Nishikawa, M. (1969) Enzymatic basis for the co-existence of myopathy and hemolytic disease in inherited muscle phosphofructokinase deficiency. Biochem. Biophys. Res. Comm., 34, 77–83.

    Article  CAS  PubMed  Google Scholar 

  • Tassin, S. and Brucher, J.M. (1982) The mitochondrial disorders: pathogenesis and aetiological classification. Neuropathol. Appl. Neurobiol., 8, 251–263.

    Article  CAS  PubMed  Google Scholar 

  • Tassin, S., Walter, G.F., Brucher, J.M. and Rousseau, J. J. (1980) Histochemical and ultrastructural analysis of the mitochondrial changes in a familial mitochondrial myopathy. Neuropathol. Appl. NeurobioL, 6, 227–247.

    Google Scholar 

  • Tobin, W.E., Hijing, F., Porro, R.S. and Salzman, R.T. (1973) Muscle phosphofructokinase deficiency. Arch. Neurol., 28, 128–130.

    Article  CAS  PubMed  Google Scholar 

  • Van der Walt, J.D., Swash, M., Leake, J. and Cox, E.L. (1987) The pattern of involvement of adult-onset acid maltase deficiency at autopsy. Muscle Nerve, 10, 272–281.

    Article  PubMed  Google Scholar 

  • Weiler, R.O. and McArdle, B. (1971) Calcification within muscle fibres in the periodic paralyses. Brain, 94, 263–272.

    Article  Google Scholar 

  • Willner, J., Di Mauro, S., Eastwood, A. et al. (1979) Muscle carnitine deficiency: genetic heterogeneity. J. Neurol. Sci., 41, 235–246.

    Article  CAS  PubMed  Google Scholar 

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© 1991 M. Swash and M.S. Schwartz

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Swash, M., Schwartz, M.S. (1991). Metabolic, endocrine and drug-induced myopathies. In: Biopsy Pathology of Muscle. Biopsy Pathology Series. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-3400-0_8

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  • DOI: https://doi.org/10.1007/978-1-4899-3400-0_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-412-34880-8

  • Online ISBN: 978-1-4899-3400-0

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