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Reactive Oxygen Species, Antioxidant Protection and Lung Injury

  • Chapter
ARDS Acute Respiratory Distress in Adults

Abstract

The syndrome of acute respiratory distress in adults (ARDS) is characterized by refractory hypoxemia secondary to nonhydrostatic pulmonary edema and is associated with a wide variety of precipitating factors, often not directly involving the lung [1,2]. Thus, ARDS can result from such diverse clinical conditions as sepsis, gastric aspiration, polytrauma, pancreatitis, hemorrhagic shock, severe burns, oxygen toxicity and cardiopulmonary bypass [2]. In spite of the increasing complexity and scientific basis of medical support, ARDS still carries a mortality rate of around 50%, little changed from when it was first described [3].

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Authors
  1. John M. C. Gutteridge
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  2. Gregory J. Quinlan
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Editor information

Editors and Affiliations

  1. National Heart & Lung Institute, USA

    Timothy W. Evans MD, FRCP, PhD (Reader in Critical Care Medicine, Consultant in Thoracic and Intensive Care Medicine) (Reader in Critical Care Medicine, Consultant in Thoracic and Intensive Care Medicine)

  2. Royal Brompton Hospital, Sydney Street, London, SW3 6NP, UK

    Timothy W. Evans MD, FRCP, PhD (Reader in Critical Care Medicine, Consultant in Thoracic and Intensive Care Medicine) (Reader in Critical Care Medicine, Consultant in Thoracic and Intensive Care Medicine)

  3. University of Edinburgh, Royal Infirmary, Lauriston Place, Edinburgh, EH3 9YW, UK

    Christopher Haslett FRCP, FRCP (Edin) (Professor of Respiratory Medicine, Chairman of the Department of Medicine (RIE) and Director of the Rayne Laboratories) (Professor of Respiratory Medicine, Chairman of the Department of Medicine (RIE) and Director of the Rayne Laboratories)

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© 1996 Springer Science+Business Media Dordrecht

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Gutteridge, J.M.C., Quinlan, G.J. (1996). Reactive Oxygen Species, Antioxidant Protection and Lung Injury. In: Evans, T.W., Haslett, C. (eds) ARDS Acute Respiratory Distress in Adults. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-3430-7_11

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  • DOI: https://doi.org/10.1007/978-1-4899-3430-7_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-412-56910-4

  • Online ISBN: 978-1-4899-3430-7

  • eBook Packages: Springer Book Archive

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