Skip to main content
SpringerLink
Log in

Laboratory Diagnosis of Alcoholism and Drug Addiction

  • Chapter
Alcohol

Part of the book series: Drugs of Abuse a Comprehensive Series for Clinicians ((DOAC,volume 2))

  • 130 Accesses

Abstract

There are no laboratory markers or histopathological findings that are specific for alcoholism. The need for greater sensitivity and specificity in the laboratory diagnosis of alcoholism continues to exist. There are sensitive and specific tests available to detect the presence of alcohol and drugs. However, these tests only confirm the use of the drugs; the syndromes of alcoholism and drug addiction must be confirmed by clinical investigation.1,2

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Salaspuro M: Conventional and coming laboratory markers of alcoholism and heavy drinking. Alcoholism: Clin and Exp Res 1986 (Supp); 10(b):5S–12S.

    Article  CAS  Google Scholar 

  2. Freedland K, Frankel MT, Evenson RC: Biochemical diagnosis of alcoholism in men psychiatric patients. J of Studies on Alcohol 1985; 46(2):103–106.

    CAS  Google Scholar 

  3. Selzer ML: The Michigan Alcoholism Screening Test: The quest for a new diagnostic instrument. Am J Psychiatry 1971; 127:89–94.

    Google Scholar 

  4. Kristenson H, Trell E, Fex G, Hood B: Serum gammaglutamyl-transferase: Statistical distribution in a middle-aged male population and evaluation of alcohol habits in individuals with elevated levels. Prev Med 1980; 9:108–119.

    Article  PubMed  CAS  Google Scholar 

  5. Kristenson H, Ohlin H, Hulten-Nosslin MB, Trell E, Hood B: Identification and intervention of heavy drinking in middle-aged men: Results and follow-up of 24-60 months of long term study with randomized controls. Alcohol Clin Exp Res 1983; 7:203–209.

    Article  PubMed  CAS  Google Scholar 

  6. Morgan MY, Colman JC, Sherlock S: The use of a combination of peripheral markers for diagnosing alcoholism and monitoring for continued abuse. Journal on Alcohol and Alcoholism 1981; 16:167–177.

    Google Scholar 

  7. Holt S, Skinner HA, Israel Y: Early identification of alcohol abuse. 2. Clinical and laboratory indicators. Can Med Assoc J 1981; 124:1279–1294.

    PubMed  CAS  Google Scholar 

  8. Rosalk SB, Rau D: Serum gamma-glutamylltranspeptidase activity in alcoholism. Clin Chim Acta 1972; 39:41–47.

    Article  Google Scholar 

  9. Chalmers DM, Rinsler MG, MacDermott S, Spicer CC, Levi AJ: Biochemical and haematological indicators of excessive alcohol consumption. Gut 1981; 22:992–996.

    Article  PubMed  CAS  Google Scholar 

  10. Whitefield JB: Alcohol-related biochemical changes in heavy drinkers. Aust NZ J Med 1981; 11:132–139.

    Article  Google Scholar 

  11. Korri U-M, Nuutinen G, Salaspuro M: Increased blood acetate: A new laboratory marker of alcoholism and heavy drinking. Alcohol Clin Exp Res 1985; 9:468–471.

    Article  PubMed  CAS  Google Scholar 

  12. Penn R, Worthington DJ: Is serum gamma-glutamyltranspep-tidase and alcohol problems. Lancet 1981; i:663.

    Google Scholar 

  13. Castelli WP, Coyle JT, Gordon T, Harnes CG, Hjortland MC, Hulley CB, Kagan A, Zuckel WJ: Alcohol and blood lipids. Lancet 1977; ii:153–155.

    Article  Google Scholar 

  14. Devenyi P, Robinson GM, Kapur BM, Roncari DAK: High-density lipoprotein cholesterol in male alcoholics with and without severe liver disease. Am J Med 1981; 71:589–594.

    Article  PubMed  CAS  Google Scholar 

  15. Jacobsson A, Norden A, Qvist J, Wadstein J: Serum ferritin—a new marker for alcoholism? Acta Soc Med Suec 1978; 87:3314.

    Google Scholar 

  16. Korsten MA, Matsuzki S, Feinman L, Liber CS: High blood ad-etaldehyde in alcoholics after ethanol administration. N Eng J Med 1975; 292:386–389.

    Article  CAS  Google Scholar 

  17. Nuutinen H, Lindros K, Hekali P, Salaspuro M: Elevated blood acetate as indicator of fast ethanol elimination in chronic alcoholics. Alcohol 1985; 2:623–626.

    Article  PubMed  CAS  Google Scholar 

  18. Stamm D, Hansert E, Feuerlein W: Excessive consumption of alcohol in men as a biological influence factor in clinical laboratory investigations. J Clin Chem Biochem 1984; 22:65–77.

    CAS  Google Scholar 

  19. Stamm D, Hansert E, Feuerlein W: Detection and exclusion of alcoholism in men on the basis of clinical laboratory findings. J Clin Chem Clin Biochem 1984; 22:79–96.

    PubMed  CAS  Google Scholar 

  20. Adams KM, Grant I: Failure of nonlinear models of drinking history variables to predict neuropsychological performance in alcoholics. Am J Psychiatry 1984; 141:663–667.

    PubMed  CAS  Google Scholar 

  21. Eckardt MJ, Feldman DJ: Biochemical correlates of alcohol abuse. In Scixas FA, ed.: Currents in Alcoholism, Vol. 3, Biological, Biochemical and Clinical Studies. New York, Grune and Strat-ton, 1978, 545–554.

    Google Scholar 

  22. Jocobson GR: Alcoholism: Detection, Assessment, and Diagnosis, New York, Human Sciences Press, Inc., 1976.

    Google Scholar 

  23. Ryback RS, Eckardt MJ, Felsher B, Rawlings RR: Biochemical and hematological correlates of alcoholism and liver disease. J Am Med Ass 1978; 248:2261–2265.

    Article  Google Scholar 

  24. Verebey K, Gold MS, Mule SJ: Laboratory testing in the diagnosis of marijuana intoxication and withdrawal. Psychiatric Annals 1986; 16(4):235–241.

    Google Scholar 

  25. Estroff TW, Gold MS: Medication and toxin induced psychiatric disorder. In Extein I, Gold MS, eds.: Medical Mimics of Psychiatric Disorders. Washington, DC, American Psychiatric Press, 1984.

    Google Scholar 

  26. Estroff TW, Gold MS: Medical and psychiatric complications of cocaine abuse and possible points of pharmacologic intervention. In Stimmel B, ed.: Advances in Alcohol and Substance Abuse 1986; 5(1/2):61–76.

    Google Scholar 

  27. Estroff TW, Gold MS: Psychiatric misdiagnosis. In Gold MS, Lydiard RB, Carman JS, eds.: Advances in Psychopharmacology: Predicting and Improving Treatment Response. Boca Raton, Fl, CRC Press, 1984, pp. 34–66.

    Google Scholar 

  28. Weissman MM, Pottenger M, Kleber H, et al: Symptom patterns in primary and secondary depression: A comparison of primary depressives with depressed opiate addicts, alcholics, and schizophrenics. Arch Gen Psychiatry 1977; 34:854–862.

    Article  PubMed  CAS  Google Scholar 

  29. Thacore VR, Shukla SRP: Cannabis psychosis and paranoid schizophrenia. Arch Gen Psychiatry 1976; 33:383–386.

    Article  PubMed  CAS  Google Scholar 

  30. Beamish P, Kiloh LG: Psychoses due to amphetamine consumption. J Ment Sci 1960; 106:337–343.

    PubMed  CAS  Google Scholar 

  31. Extein I, Dackis CA, Gold MS, et al.: Depression in drug addicts and alcoholics. In Extein I, Gold MS, eds.: Medical Mimics of Psychiatric Disorders. Washington, DC, American Psychiatric Press, 1986, pp. 133–162.

    Google Scholar 

  32. Gold MS, Estroff TW: The comprehensive evaluation of cocaine and opiate abusers. In Hall RCW, Beresford TP, eds.: Handbook of Psychiatric Diagnostic Procedures. New York, Spectrum Publications, 1985.

    Google Scholar 

  33. Gold MS, Washton AM: Adverse effects on health and functions of cocaine abuse: Data from 800-Cocaine callers. Trends, patterns and issues in drug abuse, Vol. 1, Part 2. Rockville, Md. National Institute on Drug Abuse, 1984.

    Google Scholar 

  34. Gold MS, Dackis CA, Pottash ALC, et al.: Cocaine update: From bench to bedside. In Stimmel B, ed.: Advances in Alcohol and Substance Abuse 1986; 6(2):l–5. New York, Haworth Press.

    Google Scholar 

  35. Estroff TW, Gold MS: Chronic medical complications of drug abuse. Psychiatric Medicine 1987; 3(3):267–286.

    Google Scholar 

  36. Yago KB, Pitts FN, Burgoyne RW et al.: The urban epidemic of phencyclidine (PCP) use: Clinical and laboratory evidence from a public psychiatric hospital emergency service. J Clin Psychiatry 1981; 42:193–196.

    PubMed  CAS  Google Scholar 

  37. Gold MS, Dackis CA: Role of the laboratory in the evaluation of suspected drug abuse. J Clin Psychiatry 1986; 47(1) Suppl:17–23.

    PubMed  CAS  Google Scholar 

  38. Gold MS, Pottash ALC, Estroff YW, et al.: Laboratory evaluation in treatment planning. In Karasu TB, ed.: The Psychiatric Therapies: Part 1. The Somatic Therapies. Washington, DC, APA Commission on Psychiatric Therapies, 1984.

    Google Scholar 

  39. Toxicology, Drug Abuse Survey III: August 19th Proficiency Testing. Atlanta, GA, Center for Disease Control, 1974.

    Google Scholar 

  40. Hansen HJ, Caudill SP, Boone DJ: Crisis in drug testing—Results of CDC blind study. JAMA 1985; 25:2382–2387.

    Article  Google Scholar 

  41. Gold MS, Pottash AC, Extein I: The psychiatric laboratory. In Bernstein JG, ed.: Clinical Psychopharmacology. John Wright PSG., Inc., pp. 29-58, 1984.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Cornell University Medical College, White Plains, New York, USA

    Norman S. Miller M.D.

  2. Fair Oaks Hospital, Summit, New Jersey, USA

    Mark S. Gold M.D.

  3. Delray Beach, Florida, USA

    Mark S. Gold M.D.

Authors
  1. Norman S. Miller M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mark S. Gold M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer Science+Business Media New York

About this chapter

Cite this chapter

Miller, N.S., Gold, M.S. (1991). Laboratory Diagnosis of Alcoholism and Drug Addiction. In: Alcohol. Drugs of Abuse a Comprehensive Series for Clinicians, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-3550-2_8

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-3550-2_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-3552-6

  • Online ISBN: 978-1-4899-3550-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation