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The Purification and Chemical Properties of Human Pituitary Follicle Stimulating Hormone

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Reproduction in the Female Mammal

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Abstract

Follicle stimulating hormone (FSH) of fairly high potency is easily obtained from acetone-dried or fresh frozen human pituitary glands. The purification of the hormone, however, is not so easy and traces of luteinizing hormone (LH) and proteins such as albumin remain with the FSH through many systems of chromatography, electrophoresis and salt precipitation. Moreover, the stability of FSH appears to decrease as purification proceeds and therefore the true biological potency and chemical nature of the hormone are uncertain. The present work is concerned with attempts to prepare highly purified FSH and with details of its chemical properties and the effects of certain reagents on its biological activity.

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Author information

Authors and Affiliations

  1. The United Birmingham Hospitals Department of Clinical Endocrinology, Birmingham and Midland Hospital for Women, UK

    W. R. Butt

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  1. W. R. Butt
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Editor information

Editors and Affiliations

  1. University of Nottingham, UK

    G. E. Lamming (Professor of Agriculture) (Professor of Agriculture)

  2. Royal Veterinary College, University of London, UK

    E. C. Amoroso (Professor of Physiology) (Professor of Physiology)

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© 1967 Springer Science+Business Media New York

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Butt, W.R. (1967). The Purification and Chemical Properties of Human Pituitary Follicle Stimulating Hormone. In: Lamming, G.E., Amoroso, E.C. (eds) Reproduction in the Female Mammal. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-6377-2_5

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  • DOI: https://doi.org/10.1007/978-1-4899-6377-2_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-6187-7

  • Online ISBN: 978-1-4899-6377-2

  • eBook Packages: Springer Book Archive

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