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Severity of the Parent to F1 Graft-Versus-Host Reaction in Irradiated Germfree Mice

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Germ-Free Biology Experimental and Clinical Aspects

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 3))

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Abstract

Lethally irradiated mice protected with allogeneic hemopoietic cells do not survive as long as those protected with syngeneic hemopoietic cells due to a “secondary disease.” This observation was first made by Barnes and Loutit in 1954 (l,2), and “secondary disease” was more fully characterized by Congdon and Urso in 1957 (5). This disease is primarily due to an immune reaction of grafted cells against the host tissues, the graft-versus-host (GVH) reaction (10). Uphoff (l5,l6) demonstrated a similar lesion in lethally irradiated F1 hybrid mice which had been treated with parental strain bone marrow. Schwartz, Upton, and Congdon (13) first described the “foreign spleen reaction,” a GVH disease resulting from injection of parental spleen cells into sublethally irradiated F, hybrid mice.

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References

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Authors and Affiliations

  1. Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA

    H. E. Walburg Jr. & G. E. Cosgrove

Authors
  1. H. E. Walburg Jr.
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  2. G. E. Cosgrove
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Editor information

Editors and Affiliations

  1. Roswell Park Memorial Institute, New York State Department of Health, State University of New York, Buffalo, New York, USA

    Edwin A. Mirand

  2. Canisius College, Niagara University, Niagara University, New York, Buffalo, New York, USA

    Edwin A. Mirand

  3. Department of Biochemical Pharmacology, School of Pharmacy, State University of New York, Buffalo, New York, USA

    Nathan Back

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© 1969 Springer Science+Business Media New York

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Walburg, H.E., Cosgrove, G.E. (1969). Severity of the Parent to F1 Graft-Versus-Host Reaction in Irradiated Germfree Mice. In: Mirand, E.A., Back, N. (eds) Germ-Free Biology Experimental and Clinical Aspects. Advances in Experimental Medicine and Biology, vol 3. Springer, New York, NY. https://doi.org/10.1007/978-1-4899-6495-3_35

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  • DOI: https://doi.org/10.1007/978-1-4899-6495-3_35

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4899-6234-8

  • Online ISBN: 978-1-4899-6495-3

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