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Heme Metabolism: Factors Affecting the in Vivo Oxidation of Heme

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The Year in Hematology

Abstract

The mechanism underlying the conversion of heme compounds to bile pigments has been extensively explored since the mid-1940s. Although the relationship between the formation of bilirubin and the catabolism of heme (hemoglobin) were noted as early as 1847 (Virchow), later studies by investigators such as Mann and co-workers (1926), conclusively showing that bilirubin is derived from hemoglobin, as well as later work by Fischer and Hess (1931) which identified the correct structure of bilirubin, led to a new era of investigation on heme metabolism. This chapter presents a summary of some major features of the older literature on bile pigment formation and compares and analyzes more recent developments in the field of heme oxidation and the factors influencing this process.

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Authors and Affiliations

  1. The Rockefeller University, New York, New York, 10021, USA

    Mahin D. Maines

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  1. Graduate School of Arts and Science, New York University, New York, New York, USA

    Albert S. Gordon Ph.D., F.R.S.M.  & Joseph LoBue Ph.D.  & 

  2. New York University School of Medicine, New York, New York, USA

    Robert Silber M.D.

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© 1977 Springer Science+Business Media New York

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Maines, M.D. (1977). Heme Metabolism: Factors Affecting the in Vivo Oxidation of Heme. In: Gordon, A.S., Silber, R., LoBue, J. (eds) The Year in Hematology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-6688-9_1

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  • DOI: https://doi.org/10.1007/978-1-4899-6688-9_1

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