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Hyperbilirubinemia and Antioxidant Defenses in the Neonate

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Perinatal and Prenatal Disorders

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Abstract

Bilirubin contributes to the antioxidant activity in human plasma, and the elevated concentrations of bilirubin associated with neonatal hyperbilirubinemia likely provide “additional” antioxidant defense. This chapter summarizes the different forms of bilirubin in the context of hyperbilirubinemia and how they may protect extracellular and cellular lipids and proteins from oxidative damage.

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Acknowledgments

R.S. is supported by a Senior Principal Research Fellowship from the Australian National Health and Medical Research Council (NHMRC) and the Victor Chang Cardiac Research Institute. His current research is supported by NHMRC Project Grants 1020400, 1020776, 1049381, and 1050776 and by the Australian Research Council Discovery Project 120103170.

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Authors and Affiliations

  1. Vascular Biology Division, Victor Chang Cardiac Research Institute, Lowy Packer Building, 405 Liverpool Street, Darlinghurst, NSW, 2010, Australia

    Roland Stocker Ph.D.

  2. School of Medical Sciences, Faculty of Medicine, University of New South Wales, Kensington, Australia

    Roland Stocker Ph.D.

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  1. Roland Stocker Ph.D.
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Correspondence to Roland Stocker Ph.D. .

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Editors and Affiliations

  1. University of Penn, Perelman Sch of Med Professor of Pediatrics, Children's Hospital of Philadelphia Division of Neonatology, Philadelphia, Pennsylvania, USA

    Phyllis A. Dennery

  2. Lab of Oxidative Stress Policlinico “Le Scotte“, University of Siena Dept of Peds, Obstetrics & Reprod Med, Siena, Italy

    Giuseppe Buonocore

  3. Department of Pediatrics, University of Oslo Faculty of Medicine Rikshospitalit Medical Center, Oslo, Norway

    Ola Didrik Saugstad

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Stocker, R. (2014). Hyperbilirubinemia and Antioxidant Defenses in the Neonate. In: Dennery, P., Buonocore, G., Saugstad, O. (eds) Perinatal and Prenatal Disorders. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1405-0_15

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