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Glutamine-Cycling Pathway in Metabolic Syndrome: Systems Biology-Based Characterization of the Glutamate-Related Metabolotype and Advances for Diagnosis and Treatment in Translational Medicine

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Glutamine in Clinical Nutrition

Part of the book series: Nutrition and Health ((NH))

Abstract

In this chapter we introduce the hypothesis that the glutamine-cycling pathway participates in the pathogenesis of MS and might be prominently involved in the development of the systemic underlying metabolic derangement. In addition, we postulate the critical role that some enzymatic reactions occurring in the liver tissue, such as the transamination reactions, play in the pathogenesis of MS.

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Funding Support

This study was partially supported by grants PICT 2008-1521 and 2010-0441 (Agencia Nacional de Promoción Científica y Tecnológica), and UBACYT CM04 (Universidad de Buenos Aires). SS and CJP belong to CONICET.

Potential competing interests

The authors have no conflict of interest to declare.

Author information

Authors and Affiliations

  1. Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari-IDIM, University of Buenos Aires-National Scientific and Technical Research Council, Av. Combatiente de Malvinas 3150, Ciudad Autónoma de Buenos Aires, 1427, Argentina

    Silvia Sookoian M.D., Ph.D.

  2. Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research A Lanari-IDIM, University of Buenos Aires-National Scientific and Technical Research Council, Av. Combatiente de Malvinas 3150, Ciudad Autónoma de Buenos Aires, 1427, Argentina

    Carlos J. Pirola M.D., Ph.D.

Authors
  1. Silvia Sookoian M.D., Ph.D.
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  2. Carlos J. Pirola M.D., Ph.D.
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Corresponding author

Correspondence to Silvia Sookoian M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. Department of Intensive Care, Barnet and Chase Farm Hospitals, London, United Kingdom

    Rajkumar Rajendram

  2. Department of Nutrition and Dietetics, Diabetes and Nutritional Sciences, School of Medicine, King’s College London, London, United Kingdom

    Victor R. Preedy

  3. Department of Biomedical Sciences, University of Westminster, London, United Kingdom

    Vinood B. Patel

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Sookoian, S., Pirola, C.J. (2015). Glutamine-Cycling Pathway in Metabolic Syndrome: Systems Biology-Based Characterization of the Glutamate-Related Metabolotype and Advances for Diagnosis and Treatment in Translational Medicine. In: Rajendram, R., Preedy, V., Patel, V. (eds) Glutamine in Clinical Nutrition. Nutrition and Health. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1932-1_20

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  • DOI: https://doi.org/10.1007/978-1-4939-1932-1_20

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-1931-4

  • Online ISBN: 978-1-4939-1932-1

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