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Other Pharmacological Therapies: Investigational Antiepileptic Drugs, Animal Models of Epilepsy, Hormonal Therapy, Immunotherapy

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Epilepsy Board Review

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Abstract

The investigation of antiepileptic drugs (AEDs) includes trials of new routes of delivery for marketed drugs, trials of marketed drugs for new indications, and trials of novel compounds. New routes of delivery are being tested in particular for benzodiazepines, in the treatment of seizure clusters by family members and other nonmedical caregivers. A large pivotal trial was completed for intramuscular diazepam administration by autoinjector, demonstrating intramuscular diazepam to be superior to placebo in preventing additional seizures and in obviating the need for other rescue treatment or emergency room visit.

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Author information

Authors and Affiliations

  1. Neurology, Comprehensive Epilepsy Program, Vanderbilt University Medical Center, Nashville, TN, USA

    Bassel Abou-Khalil

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  1. Bassel Abou-Khalil
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Correspondence to Bassel Abou-Khalil .

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Editors and Affiliations

  1. Director, Epilepsy Center, George Washington University Director, Epilepsy Center, Washington, District of Columbia, USA

    Mohamad Z. Koubeissi

  2. Vanderbilt University Medical Center, Intra-operative Neuro-monitoring Program Vanderbilt University Medical Center, Nashville, Tennessee, USA

    Nabil J. Azar

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Abou-Khalil, B. (2017). Other Pharmacological Therapies: Investigational Antiepileptic Drugs, Animal Models of Epilepsy, Hormonal Therapy, Immunotherapy. In: Koubeissi, M., Azar, N. (eds) Epilepsy Board Review. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-6774-2_19

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  • DOI: https://doi.org/10.1007/978-1-4939-6774-2_19

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-6772-8

  • Online ISBN: 978-1-4939-6774-2

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