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Interactions Between Growth Hormone Secretion and Sleep

  • Chapter
Human Growth Hormone

Part of the book series: Contemporary Endocrinology ((COE,volume 19))

Abstract

The fact that the secretion of growth hormone (GH) is markedly stimulated during sleep has been recognized for more than three decades. Early studies using the first available radioimmunoassays for GH demonstrated that the peripheral levels of this hormone increased rapidly following sleep onset (1–5). In normal adult subjects, the 24-h profile of plasma GH levels consists of stable low levels abruptly interrupted by bursts of secretion. The most reproducible pulse occurs shortly after sleep onset (3,4). This relationship between sleep onset and GH secretion appears to be most consistent in the human species, because it is more difficult to evidence in other mammals, although elevated blood GH levels have been observed during sleep in baboons, rhesus monkeys, dogs, lambs, and both immature and adult rats (6–12). Species differences could be related to the fact that human sleep is consolidated in a single 7 to 9-h period, whereas multiple sleep bouts are the rule in other mammals. Thus, the sleep-wake transition in the human is generally associated with more pronounced variations in endocrine, metabolic, and other parameters than in other species.

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References

  1. Quabbe H, Schilling E, Helge H. Pattern of growth hormone secretion during a 24-hour fast in normal adults. J Clin Endocr Metab 1966; 26: 1173–1177.

    Article  PubMed  CAS  Google Scholar 

  2. Hunter WM, Rigal WM. The diurnal pattern of plasma growth hormone concentration in children and adolescents. J Endocr 1966; 34: 147–153.

    Article  PubMed  CAS  Google Scholar 

  3. Takahashi Y, Kipnis DM, Daughaday WH. Growth hormone secretion during sleep. J Clin Invest 1968; 47: 2079–2090.

    Article  PubMed  CAS  Google Scholar 

  4. Sassin JF, Parker DC, Mace JW, Gotlin RW, Johnson LC, Rossman LG. Human growth hormone release: relation to slow-wave sleep and sleep-waking cycles. Science 1969; 165: 513–515.

    Article  PubMed  CAS  Google Scholar 

  5. Honda Y, Takahashi K, Takahashi S, Azumi K, trie M, Skuma M, Tsushima T, Shizume K. Growth hormone secretion during nocturnal sleep in normal subjects. J Clin Endocrinol Metab 1969; 29: 20–29.

    Article  PubMed  CAS  Google Scholar 

  6. Parker D, Morishima M, Koerker D, Gale C, Goodner C. Pilot study of growth hormone release in sleep of the chair-adapted baboon: potential as model of human sleep release. Endocrinology 1972; 91: 1462–1467.

    Article  PubMed  CAS  Google Scholar 

  7. Takahashi Y, Ebihara S, Nakamura Y, Takahashi K. A model of human sleep-related growth hormone secretion in dogs: Effects of 3, 6, and 12 hours of forced wakefulness on plasma growth hormone, cortisol, and sleep stages. Endocrinology 1981; 109: 262–272.

    CAS  Google Scholar 

  8. Kawakami M, Kimura F, Tsai C-W. Correlation of growth hormone secretion to sleep in the immature rat. J Physiol 1983; 339: 325–337.

    PubMed  CAS  Google Scholar 

  9. Kimura F, Tsai C-W. Utradian rhythm of growth hormone secretion and sleep in the adult male rat. J Physiol 1984; 353: 305–315.

    PubMed  CAS  Google Scholar 

  10. Mitsugi N, Kimura F. Simultaneous determinations of corticosterone and growth hormone in the male rat: relation to sleep-wakefulness cycle. Neuroendocrinology 1985; 41: 125–130.

    Article  PubMed  CAS  Google Scholar 

  11. Kaler LW, Gliessman P, Craven J, Hill J, Critchlow V. Loss of enhanced nocturnal growth hormone secretion in aging rhesus males. Endocrinology 1986; 119: 1281–1284.

    Article  PubMed  CAS  Google Scholar 

  12. Laurentie MP, Barenton B, Charrier J, Garcia-Villar R, Marnet PG, Blanchard M, Toutain PL. Instantaneous secretion rate of growth hormone in lambs: relationships with sleep, food intake, and posture. Endocrinology 1989; 125: 642–651.

    Article  PubMed  CAS  Google Scholar 

  13. Ho KY, Evans WS, Blizzard RM, Veldhuis JD, Merriam GR, Samojlik E, Furlanetto R, Rogol AD, Kaiser DL, Thorner MO. Effects of sex and age on the 24-hour profile of growth hormone secretion in man: importance of endogenous estradiol concentrations. J Clin Endocrinol Metab 1987; 64: 51–58.

    Article  PubMed  CAS  Google Scholar 

  14. Van Cauter E, Kerkhofs M, Caufriez A, Van Onderbergen A, Thorner MO, Copinschi G. A quantitative estimation of GH secretion in normal man: reproducibility and relation to sleep and time of day. J Clin Endocrinol Metab 1992; 74: 1441–1450.

    Article  PubMed  Google Scholar 

  15. Weibel L, Spiegel K, Gronfier C, Follenius M, Brandenberger G. Twenty-four-hour melatonin and core body temperature rhythms: their adaptation in night workers. Am J Physiol 1997; 272: R948 - R954.

    PubMed  CAS  Google Scholar 

  16. Pietrowsky R, Meyrer R, Kern W, Born J, Fehm H. Effects of diurnal sleep on secretion of cortisol, luteinizing hormone, and growth hormone in man. J Clin Endocrinol Metab 1994; 78: 683–687.

    Article  PubMed  CAS  Google Scholar 

  17. Van Cauter E, Blackman JD, Roland D, Spire JP, Refetoff S, Polonsky KS. Modulation of glucose regulation and insulin secretion by circadian rhythmicity and sleep. J Clin Invest 1991; 88: 934–942.

    Article  PubMed  Google Scholar 

  18. Davidson JR, Moldofsky H, Lue FA. Growth hormone and cortisol secretion in relation to sleep and wakefulness. J Psychiatr Neurosci 1991; 16: 96–102.

    CAS  Google Scholar 

  19. Golstein J, Van Cauter E, Desir D, Noel P, Spire J, Refetoff S, Copinschi G. Effects of “jet lag” on hormonal patterns. IV. Time shifts increase growth hormone release. J Clin Endocrinol Metab 1983; 56: 433–440.

    Article  PubMed  CAS  Google Scholar 

  20. Othmer E, Mendelson WB, Levine WR, Malarkey WB, Daughaday WH. Sleep-related growth hormone secretion and morning naps. Steroids Lipids Res 1974; 5: 380–386.

    PubMed  CAS  Google Scholar 

  21. Karacan I, Rosenbloom AL, Londono JH, Williams RL, Salis PJ. Growth hormone levels during morning and afternoon naps. Behav Neuropsychiatry 1974; 6: 67–70.

    PubMed  CAS  Google Scholar 

  22. Weitzman ED, Nogeire C, Perlow M, Sassin JF, Fukushima D, McGregor P, Gallagher TF, Hellman L. Effects of a prolonged 3-hour sleep-wake cycle on sleep stages, plasma cortisol, growth hormone and body temperature in man. J Clin Endocrinol Metab 1974; 38: 1018–1030.

    Article  PubMed  CAS  Google Scholar 

  23. Weitzman E, Czeisler C, Zimmerman J, Ronda J. The sleep-wake pattern of cortisol and growth hormone secretion during non-entrained (free-running) conditions in man. In: Van Cauter E, Copinschi G, eds. Human Pituitary Hormones: Circadian and Episodic Variations. Martinus Nijhoff, The Hague, 1981, pp. 29–41.

    Google Scholar 

  24. Moline M, Monk T, Wagner D, Pollak C, Kream J, Fookson J, Weitzman E, Czeisler C. Human growth hormone release is decreased during sleep in temporal isolation (free-running). Chronobiologia 1986; 13: 13–19.

    PubMed  CAS  Google Scholar 

  25. Beck U, Brezinova V, Hunter WM, Oswald I. Plasma growth hormone and slow wave sleep increase after interruption of sleep. J Clin Endocrinol Metab 1975; 40: 812–815.

    Article  PubMed  CAS  Google Scholar 

  26. Aschoff J. Circadian rhythms: general features and endocrinological aspects. In: Krieger DT, ed. Endocrine Rhythms. Raven, New York, 1979, pp. 1–61.

    Google Scholar 

  27. Mullington J, Hermann D, Holsboer F, Pollmacher T. Age-dependent suppression of nocturnal growth hormone levels during sleep deprivation. Neuroendocrinology 1996; 64: 233–241.

    Article  PubMed  CAS  Google Scholar 

  28. Seifritz E, Hemmeter U, Trachsel L, Lauer C, Hatzinger M, Emrich H, Holsboer F, Holsboer-Trachsler E. Effects of flumazenil on recovery sleep and hormonal secretion after sleep deprivation in male controls. Psychopharmacology (Berl) 1995; 120: 449–456.

    Article  CAS  Google Scholar 

  29. Jaffe C, Turgeon D, DeMott Friberg R, Watkins P, Barkan A. Nocturnal augmentation of growth hormone (GH) secretion is preserved during repetitive bolus administration of GH-releasing hormone: potential involvement of endogenous somatostatin–A clinical research center study. J Clin Endocrinol Metab 1995; 80: 3321–3326.

    Article  PubMed  CAS  Google Scholar 

  30. Rechtschaffen A, Kales A. A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects. Abbreviated Journal, 1968.

    Google Scholar 

  31. Parker DC, Sassin JF, Mace JW, Gotlin RW, Rossman LG. Human growth hormone release during sleep: electroencephalographic correlations. J Clin Endocr Metab 1969; 29: 871–874.

    Article  PubMed  CAS  Google Scholar 

  32. Sassin J, Parker D, Johnson L, Rossman L, Mace J, Gotlin R. Effects of slow wave sleep deprivation on human growth hormone release in sleep: Preliminary study. Life Sciences 1969; 8: 1299–1307.

    CAS  Google Scholar 

  33. Karacan I, Rosenbloom AL, Williams RL, Finley WW, Hursch CJ. Slow Wave sleep deprivation in relation to plasma growth hormone concentration. Behav Neuropsychiatry 1971: 2: 11–14.

    PubMed  CAS  Google Scholar 

  34. Pawel M, Sassin J, Weitzman E. The temporal relation between HGH release and sleep stage changes at nocturnal sleep onset in man. Life Sciences 1972; 11: 587–593.

    Article  CAS  Google Scholar 

  35. Steiger A, Herth T, Holsboer F. Sleep-electroencephalography and the secretion of cortisol and growth hormone in normal controls. Acta Endocrinol 1987; 116: 36–42.

    PubMed  CAS  Google Scholar 

  36. Born J, Muth S, Fehm HL. The significance of sleep onset and slow wave sleep for nocturnal release of growth hormone (GH) and cortisol. Psychoneuroendocrinology 1988; 13: 233–243.

    Article  PubMed  CAS  Google Scholar 

  37. Jarrett DB, Greenhouse JB, Miewald JM, Fedorka IB, Kupfer DJ. A reexamination of the relationship between growth hormone secretion and slow wave sleep using delta wave analysis. Biol Psychiatry 1990; 27: 497–509.

    Article  PubMed  CAS  Google Scholar 

  38. Mendlewicz J, Linkowski P, Kerkhofs M, Desmedt D, Golstein J, Copinschi G, Van Cauter E. Diurnal hypersecretion of growth hormone in depression. J Clin Endocrinol Metab 1985; 60: 505–512.

    Article  PubMed  CAS  Google Scholar 

  39. Holl RW, Hartmann ML, Veldhuis JD, Taylor WM, Thorner MO. Thirty-second sampling of plasma growth hormone in man: correlation with sleep stages. J Clin Endocrinol Metab 1991; 72: 854–861.

    Article  PubMed  CAS  Google Scholar 

  40. Gronfier C, Luthringer R, Follenius M, Schaltenbrand N, Macher JP, Muzet A, Brandenberger G. A quantitative evaluation of the relationships between growth hormone secretion and delta wave electroencephalographic activity during normal sleep and after enrichment in delta waves. Sleep 1996; 19: 817–824.

    PubMed  CAS  Google Scholar 

  41. Van Cauter E, Caufriez A, Kerkhofs M, Van Onderbergen A, Thorner MO, Copinschi G. Sleep, awakenings and insulin-like growth factor I modulate the growth hormone secretory response to growth hormone-releasing hormone. J Clin Endocrinol Metab 1992; 74: 1451–1459.

    Article  PubMed  Google Scholar 

  42. Spath-Schwalbe E, Hundenborn C, Kern W, Fehm H, Born J. Nocturnal wakefulness inhibits growth hormone (GH)-releasing hormone-induced GH secretion. J Clin Endocrinol Metab 1995; 80: 214–219.

    Article  PubMed  CAS  Google Scholar 

  43. Van Cauter E, van Coevorden A, Blackman JD. Modulation of neuroendocrine release by sleep and circadian rhythmicity. In: Yen S, Vale W, eds. Advances in neuroendocrine regulation of reproduction. Serono Symposia USA, Norwell, 1990, pp. 113–122.

    Google Scholar 

  44. Barbarino A, Corsello SM, Della Casa S, Tofani A, Sciuto R, Rota CA, Bollanti L, Barini A. Corticotropin-releasing hormone inhibition of growth hormone-releasing hormone-induced growth hormone release in man. J Clin Endocrinol Metab 1990; 71: 1368–1374.

    Article  PubMed  CAS  Google Scholar 

  45. Bliwise DL. Sleep in normal aging and dementia. Sleep 1993; 16: 40–81.

    PubMed  CAS  Google Scholar 

  46. van Coevorden A, Mockel J, Laurent E, Kerkhofs M, L’Hermite-Balériaux M, Decoster C, Nève P, Van Cauter E. Neuroendocrine rhythms and sleep in aging. Am J Physiol 1991; 260: E651 - E661.

    PubMed  Google Scholar 

  47. Copinschi G, Van Onderbergen A, L’Hermite-Balériaux M, Szyper M, Caufriez A, Bosson D, L’Hermite M, Robyn C, TurekFW, Van Cauter E. Effects of the short-acting benzodiazepine triazolam, taken at bedtime, on circadian and sleep-related hormonal profiles in normal men. Sleep 1990; 13: 232–244.

    CAS  Google Scholar 

  48. Scharf MB. Pharmacology of classic and novel hypnotic drugs. In: Langer SZ, Mendlewicz J, Racagni C, eds. Target receptors for anxiolytics and hypnotics: From molecular pharmacology to therapeutics. Karger, Basel, 1992, pp. 109–116.

    Google Scholar 

  49. Copinschi G, Akseki E, Moreno-Reyes R, Leproult R, L’Hermite-Balériaux M, Caufriez A, Vertongen F, Van Cauter E. Effects of bedtime administration of zolpidem on circadian and sleep-related hormonal profiles in normal women. Sleep 1995; 18: 417–424.

    PubMed  CAS  Google Scholar 

  50. Mamelak M, Escriu JM, Stokan O. The effects of gamma-hydroxybutyrate on sleep. Biol Psychiatry 1977; 12: 273–288.

    PubMed  CAS  Google Scholar 

  51. Scharf MB, Brown D, Woods M, Brown L, Hirschowitz J. The effects and effectiveness of gamma-hydroxybutyrate in patients with narcolepsy. J Clin Psychiatry 1985; 46: 222–225.

    PubMed  CAS  Google Scholar 

  52. Mamelak M, Scharf MB, Woods M. Treatment of narcolepsy with gamma-hydroxybutyrate. A review of clinical and sleep laboratory findings. Sleep 1986; 9: 285–289.

    PubMed  CAS  Google Scholar 

  53. Lapierre O, Montplaisir J, Lamarre M, Bedard MA. The effects of gamma-hydroxybutyrate on nocturnal and diurnal sleep of normal subjects: further consideration on REM-sleep triggering mechanisms. Sleep 1990; 13: 24–30.

    PubMed  CAS  Google Scholar 

  54. Series F, Series I, Cormier Y. Effects of enhancing slow-wave sleep by gamma-hydroxybutyrate on obstructive sleep apnea. Am Rev Respir Dis 1992; 145: 1378–1383.

    PubMed  CAS  Google Scholar 

  55. Lammers GJ, Arends J, Declerck AC, Ferrari MD, Schouwink G, Troost J. Gammahydroxybutyrate and narcolepsy: A double-blind placebo-controlled study. Sleep 1993; 16: 216–220.

    PubMed  CAS  Google Scholar 

  56. Mamelak M. Gamma-hydroxybutyrate: An endogenous regulator of energy metabolism. Neurose wangwu Biobehav Rev 1989; 13: 187–198.

    Article  CAS  Google Scholar 

  57. Tunnicliff G. Significance of gamma-hydroxybutyrate in the brain. Gen Pharmac 1992; 23; 1027–1034.

    Article  CAS  Google Scholar 

  58. Cash CD. Gammahydroxybutyrate: An overview of the pros and cons for it being a neurotransmitter and/or a useful therapeutic agent. Neurosci wangwu Biobehav Rev 1994; 18: 291–304.

    Article  CAS  Google Scholar 

  59. Van Cauter E, Plat L, Scharf M, Leproult R, Cespedes S, L’Hermite-Balériaux M, Copinschi G. Simultaneous stimulation of slow-wave sleep and growth hormone secretion by gamma-hydroxybutyrate in normal young men. J Clin Invest 1997; 100: 745–753.

    Article  PubMed  Google Scholar 

  60. Miller JD, Esparza A, Wright NM, Garimella V, Lai J, Lester SE, Mosier HDJ. Spontaneous growth hormone release in term infants: changes during the first four days of life. J Clin Endocrinol Metab 1993; 76: 1058–1062.

    Article  PubMed  CAS  Google Scholar 

  61. Costin G, Ratner Kaufman F, Brasel JA. Growth hormone secretory dynamics in subjects with normal stature. J Pediatr 1989; 115: 537–544.

    Article  PubMed  CAS  Google Scholar 

  62. Mauras N, Blizzard RM, Link K, Johnson ML, Rogol AD, Veldhuis JD. Augmentation of growth hormone secretion during puberty: evidence for a pulse amplitude-modulated phenomenon. J Clin Endocrinol Metab 1987; 64: 596–601.

    Article  PubMed  CAS  Google Scholar 

  63. Rose SR, Municchi G, Barnes KM, Kamp GA, Uriarte MM, Ross JL, Cassorla F, Cutler GBJ. Spontaneous growth hormone secretion increases during puberty in normal girls and boys. J Clin Endocrinol Metab 1991; 73: 428–435.

    Article  PubMed  CAS  Google Scholar 

  64. Mace JW, Gotlin RW, Beck P. Sleep related human growth hormone (GH) release: A test of physiologic growth hormone secretion in children. J Clin Endocrinol Metab 1972; 34: 339–341.

    Article  PubMed  CAS  Google Scholar 

  65. Rosenfield RL, Cara JF. Somatic growth and maturation. In: DeGroot LJ, ed. Endocrinology, 3rd ed. WB Saunders, Philadelphia, 1995, pp. 2549–2589.

    Google Scholar 

  66. Eastman C, Lazarus L. Growth hormone release during sleep in growth retarded children. Arch Dis Child 1973; 48: 502–507.

    Article  PubMed  CAS  Google Scholar 

  67. Stahl M, Orr W, Griffiths W. Nocturnal levels of growth hormone in hyperactive children of small stature. J Clin Psychiatry 1979; 40: 225–227.

    PubMed  CAS  Google Scholar 

  68. Hindmarsh P, Smith P, Taylor B, Pringle P, Brook C. Comparison between a physiological and a pharmacological stimulus of growth hormone secretion: response to stage IV sleep and insulin-induced hypoglycaemia. Lancet 1985; 2 (8463): 1033–1035.

    Article  PubMed  CAS  Google Scholar 

  69. Tapanainen P, Rantala H, Leppaluoto J, Lautala P, Kaar M, Knip M. Nocturnal release of immunoreactive growth hormone-releasing hormone and growth hormone in normal children. Pediatr Res 1989; 26: 404–409.

    Article  PubMed  CAS  Google Scholar 

  70. Prinz PN, Vitiello MV, Raskind MA, Thorpy MJ. Geriatrics: sleep disorders and aging. N Engl J Med 1990; 323: 520–526.

    Article  PubMed  CAS  Google Scholar 

  71. Landin-Wilhelmsen K, Wilhelmsen L, Lappas G, Rosen T, Lindstedt G, Lundberg P, Bengtsson B. Serum insulin-like growth factor I in a random population sample of men and women: relation to age, sex, smoking habits, coffee consumption and physical activity, blood pressure and concentrations of plasma lipids, fibrinogen, parathyroid hormone and osteocalcin. Clin Endocrinol 1994; 41: 351–357.

    Article  CAS  Google Scholar 

  72. Prinz PN. Sleep and sleep disorders in older adults. J Clin Neurophysiol 1995; 12: 139–146.

    Article  PubMed  CAS  Google Scholar 

  73. Finkelstein JW, Roffwarg HP, Boyar RM, Kream J, Hellman L. Age-related change in the twenty-four-hour spontaneous secretion of growth hormone. J Clin Endocrinol Metab 1972; 35: 665–670.

    Article  PubMed  CAS  Google Scholar 

  74. Vermeulen A. Nyctohemeral growth hormone profiles in young and aged men: correlation with somatomedin-C levels. J Clin Endocrinol Metab 1987; 64: 884–888.

    Article  PubMed  CAS  Google Scholar 

  75. Iranmanesh A, Lizarralde G, Veldhuis JD. Age and relative adiposity are specific negative determinants of the frequency and amplitude of growth hormone (GH) secretory bursts and the half-life of endogenous GH in healthy men. J Clin Endocrinol Metab 1991; 73: 1081–1088.

    Article  PubMed  CAS  Google Scholar 

  76. Frank S, Roland DC, Sturis J, Byrne MM, Spire JP, Refetoff S, Polonsky KS, Van Cauter E. Effects of aging on glucose regulation during wakefulness and sleep. Am J Physiol 1995; 269: E1006 - E1016.

    PubMed  CAS  Google Scholar 

  77. Copinschi G, Van Cauter E. Effects of ageing on modulation of hormonal secretions by sleep and circadian rhythmicity. Horm Res 1995; 43: 20–24.

    Article  PubMed  CAS  Google Scholar 

  78. Kern W, Dodt C, Born J, Fehm HL. Changes in cortisol and growth hormone secretion during nocturnal sleep in the course of aging. J Gerontol 1996; 51A: M3 - M9.

    CAS  Google Scholar 

  79. Prinz P, Moe K, Dulberg E, Larsen L, Vitiello M, Toivola B, Merriam G. Higher plasma IGF-1 levels are associated with increased delta sleep in healthy older men. J Gerontol 1995; 50A: M222 - M226.

    CAS  Google Scholar 

  80. Carlson HE, Gillin JC, Gorden P, Snyder F. Absence of sleep-related growth hormone peaks in aged normal subjects and in acromegaly. J Clin Endocrinol Metab 1972; 34: 1102–1105.

    Article  PubMed  CAS  Google Scholar 

  81. Tsai J, Zorrilla L, Jacob K, Rosenberg S, Marcus D. Nocturnal monitoring of growth hormone, insulin, C-Peptide, and glucose in patients with acromegaly. Am J Med Sci 1996; 311: 281–285.

    Article  PubMed  CAS  Google Scholar 

  82. Goldstein SJ, Wu RHK, Thorpy MJ, Shprintzen RJ, Marion RE, Saenger P. Reversibility of deficient sleep entrained growth hormone secretion in a boy with achondroplasia and obstructive sleep apnea. Acta Endocrinol 1987; 116: 95–101.

    PubMed  CAS  Google Scholar 

  83. Saini J, Krieger J, Brandenberger G, Wittersheim G, Simon C, Follenius M. Continuous positive airway pressure treatment: Effects on growth hormone, insulin and glucose profiles in obstructive sleep apnea patients. Hormone Metab Res 1993; 25: 375–381.

    Article  CAS  Google Scholar 

  84. Cooper BG, White JES, Ashworth LA, Alberti KGMM, Gibson GJ. Hormonal and metabolic profiles in subjects with obstructive sleep apnea syndrome and the effects of nasal continuous positive airway pressure (CPAP) treatment. Sleep 1995; 18: 172–179.

    PubMed  CAS  Google Scholar 

  85. Van Cauter E, Polonsky KS, Blackman JD, Roland D, Sturis J, Byrne MM, Scheen AJ. Abnormal temporal patterns of glucose tolerance in obesity: relationship to sleep-related growth hormone and circadian cortisol rhythmicity. J Clin Endocrinol Metab 1994; 79: 1797–1805.

    Article  PubMed  Google Scholar 

  86. Radomski MW, Buguet A, Doua F, Bogui P, Tapie P. Relationship of plasma growth hormone to slow wave sleep in African sleeping sickness. Neuroendocrinology 1996; 63: 393–396.

    Article  PubMed  CAS  Google Scholar 

  87. Steiger A, von Bardeleben U, Herth T, Holsboer F. Sleep EEG and nocturnal secretion of cortisol and growth hormone in male patients with endogenous depression before treatment and after recovery. J Affect Disord 1989; 16: 189–195.

    Article  PubMed  CAS  Google Scholar 

  88. Jarrett DB, Miewald JM, Kupfer DJ. Recurrent depression is associated with a persistent reduction in sleep-related growth hormone secretion. Arch Gen Psychiatry 1990; 47: 113–118.

    Article  PubMed  CAS  Google Scholar 

  89. Zhang J, Obal FJ, Fang J, Collins BJ, Krueger JM. Non-rapid eye movement sleep is suppressed in transgenic mice with a deficiency in the somatotropic system. Neurose Lett 1996; 220: 97–100.

    Article  CAS  Google Scholar 

  90. Aström C, Lindholm J. Growth Hormone deficient young adults have decreased deep sleep. Neuroendocrinol 1990; 51: 82–84.

    Article  Google Scholar 

  91. Aström C, Jochumsen PL. Decrease in delta sleep in growth hormone deficiency assessed by a new power spectrum analysis. Sleep 1989; 12: 508–515.

    PubMed  Google Scholar 

  92. Aström C. Interaction between sleep and growth hormone evaluated by manual polysomnography and automatic power spectral analysis. Acta Neurol Scand 1995; 92: 281–296.

    Article  PubMed  Google Scholar 

  93. Lachmansingh E, Rollo CD. Evidence for a trade-off between growth and behavioural activity in giant “Supermice” genetically engineered with extra growth hormone genes. Can J Zool 1994; 72: 2158–2168.

    Article  Google Scholar 

  94. Drucker-Colin RR, Spanis CW, Hunyadi J, Sassin JR, McGaugh JL. Growth hormone effects on sleep and wakefulness in the rat. Neuroendocrinology 1975; 18: 1–8.

    Article  PubMed  CAS  Google Scholar 

  95. Stern W, Jalowiec J, Shabshelowitz H, Morgane P. Effects of growth hormone on sleep-waking patterns in cats. Horm Behav 1975; 6: 189–196.

    Article  PubMed  CAS  Google Scholar 

  96. Mendelson WB, Slater S, Gold P, Gillin JC. The effect of growth hormone administration on human sleep: a dose-response study. Biol Psychiatry 1980; 15: 613–618.

    PubMed  CAS  Google Scholar 

  97. Kern W, Halder R, Al-Reda S, Späth-Schwalbe E, Fehm HL, Born J. Systemic growth hormone does not affect human sleep. J Clin Endocrinol Metab 1993; 76: 1428–1432.

    Article  PubMed  CAS  Google Scholar 

  98. Obâl FJ, Payne L, Kapas L, Opp M, Krueger JM. Inhibition of growth hormone-releasing factor suppresses both sleep and growth hormone secretion in the rat. Brain Res 1991; 557: 149–153.

    Article  PubMed  Google Scholar 

  99. Ehlers CL, Reed TK, Henriksen SJ. Effects of corticotropin-releasing factor and growth hormone-releasing factor on sleep and activity in rats. Neuroendocrinology 1986; 42: 467–474.

    Article  PubMed  CAS  Google Scholar 

  100. Nistico G, De Sarro GB, Bagetta G, Müller EE. Behavioral and electrocortical spectrum power effects of growth hormone releasing factor in rats. Neuropharmacology 1987; 26: 75–78.

    Article  PubMed  CAS  Google Scholar 

  101. Obâl FJ, Alfödi P, Cady AP, Johannsen L, Sary G, Krueger, JM. Growth hormone-releasing factor enhances sleep in rats and rabbits. Am J Physiol 1988; 255: R310 - R316.

    PubMed  Google Scholar 

  102. Obâl F, Floyd R, Kapas L, Bodosi B, Krueger JM. Effects of systemic GHRH on sleep in intact and hypophysectomized rats. Am J Physiol (Endocrinol Metab) 1996; 270: E230 - E237.

    Google Scholar 

  103. Obâl FJ, Payne L, Opp MR, Alfoldi P, Kapas L, Krueger JM. Growth hormone-releasing hormone antibodies suppress sleep and prevent enhancement of sleep after sleep deprivation. Am J Physiol (Endocrinol Metab) 1992; 263: R1078 - R1085.

    Google Scholar 

  104. Garry P, Roussel B, Cohen R, Biot-Laporte S, Elm Charfi A, Jouvet M, Sassolas G. Diurnal administration of human growth hormone-releasing factor does not modify sleep and sleep-related growth hormone secretion in normal young men. Acta Endocrinol (Copenh) 1985; 110: 158–163.

    CAS  Google Scholar 

  105. Kupfer DJ, Jarrett DB, Ehlers CL. The effect of GRF on the EEG sleep of normal males. Sleep 1991; 14: 87–88.

    PubMed  CAS  Google Scholar 

  106. Marshall L, Mölle M, Böschen G, Steiger A, Fehm HL, Born J. Greater efficacy of episodic than continuous growth hormone-releasing hormone (GHRH) administration in promoting slow-wave sleep (SWS). J Clin Endocrinol Metab 1996; 81: 1009–1013.

    Article  PubMed  CAS  Google Scholar 

  107. Steiger A, Guldner J, Hemmeter U, Rothe B, Wiedemann K, Holsboer F. Effects of growth hormone-releasing hormone and somatostatin on sleep EEG and nocturnal hormone secretion in male controls. Neuroendocrinol 1992; 56: 566–573.

    Article  CAS  Google Scholar 

  108. Kerkhofs M, Van Cauter E, Van Onderbergen A, Caufriez A, Thorner MO, Copinschi G. Sleep-promoting effects of growth hormone-releasing hormone in normal men. Am J Physiol 1993; 264: E594 - E598.

    PubMed  CAS  Google Scholar 

  109. Guldner J, Friess E, Colla-Muller M, Schier T, Holsboer F, Steiger A. Influence of growth hormone-releasing hormone (GHRH) on sleep EEG and on nocturnal secretion of cortisol, ACTH and growth hormone in elderly normal controls. Exp Clin Endocrinol 1994; 102 (Suppl 1), 69.

    Google Scholar 

  110. Schier T, Guldner J, Colla M, Holsboer F, Steiger A. Changes in sleep-endocrine activity after growth hormone-releasing hormone depend on time of administration. J Neuroendocrinol 1997; 9: 201–205.

    Article  PubMed  CAS  Google Scholar 

  111. Danguir J, de Saint-Hilaire-Kafi S. Somatostatin antiserum blocks carbachol-induced increase of paradoxical sleep in rat. Brain Res Bull 1988; 20: 9–12.

    Article  PubMed  CAS  Google Scholar 

  112. Danguir J. Intracerebroventricular infusions of somatostatin selectively increase paradoxical sleep in rats. Brain Res 1986; 367: 26–30.

    Article  PubMed  CAS  Google Scholar 

  113. Beranek L, Obâl FJ, Bodosi B, Taishi P, Lacsi F, Krueger J. Inhibition of non-REM sleep in response to a long-acting somatostatin analog, sandostatin, in the rat. J Sleep Res 1996; 5 (Suppl 1), 14.

    Google Scholar 

  114. Kupfer Di, Jarrett DB, Ehlers CL. The effect of SRIF on the EEG sleep of normal men. Psychoneuroendocrinol 1992; 17: 37–43.

    Article  Google Scholar 

  115. Steiger A, Frieboes R, Colla-Müller M, Guldner J, Murck H, Schier T, Holsboer F. Opposite effects of growth hormone-releasing hormone and somatostatin on the sleep EEG in elderly controls. Pharmacopsychiatry 1995; 28: 218.

    Google Scholar 

  116. Howard AD, Feighner SD, Cully DF, Arena JP, Liberator PA, Rosenblum CI, Hamelin M, Hrenuk DL, Palyha OC, Anderson J, Paress PS, Diaz C, Chou M, Liu KK, McKee KK, Pong SS, Chaung L, Elbrecht A, Dashkevicz M, Heavens R, Rigby M, Sirinathsinghji D, Dean DC, Mellilo DG, Patchett AA, Nargund R, Griffin PR, DeMartino JA, Gupta SK, Schaeffer JM, Smith RG, Van der Ploeg LHT. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 1996; 273: 974–977.

    Article  PubMed  CAS  Google Scholar 

  117. Conn PM, Bowers CY. A new receptor for growth hormone-release peptide. Science 1996; 273: 923.

    Article  PubMed  CAS  Google Scholar 

  118. Smith RG, Pong SS, Hickey G, Jacks T, Cheng K, Leonard R, Cohen CJ, Arena JP, Chang CH, Drisko J, Wyvratt M, Fisher M, Nargund R, Patchett A. Modulation of pulsatile GH release through a novel receptor in the hypothalamus and pituitary gland. In: Recent Progress in Hormone Research ed. The Endocrine Society, Bethesda, Md, 1996, pp. 261–286.

    Google Scholar 

  119. Frieboes R-M, Murck H, Maier P, Schier T, Holsboer F, Steiger A. Growth hormone-releasing petide6 stimulates sleep, growth hormone, ACTH and cortisol release in normal man. Neuroendocrinol 1995; 61: 584–589.

    Article  CAS  Google Scholar 

  120. Moreno-Reyes R, Kerkhofs M, L’Hermite-Baleriaux M, Thorner M, Van Cauter E, Copinschi G. Evidence against the involvement of the growth hormone-releasing peptide axis in human slow-wave sleep regulation (submitted).

    Google Scholar 

  121. Patchett AA, Nargund RP, Tata JR, Chen M-H, Barakat KJ, Johnston DBR, Cheng K, Chan WW-S, Butler B, Hickey G, Jacks T, Schleim K, Pong S-S, Chaung L-YP, Chen HY, Frazier E, Leung KH, Chiu S-HL, Smith RG. Design and biological activities of L-163,191 (MK-0677): A potent, orally active growth hormone secretagogue. Proc Natl Acad Sci USA 1995; 92: 7001–7005.

    Article  PubMed  CAS  Google Scholar 

  122. Copinschi G, Van Onderbergen A, L’Hermite-Balériaux M, Mendel CM, Caufriez A, Leproult R, Bolognese JA, De Smet M, Thorner MO, Van Cauter E. Effects of a 7-day treatment with a novel orally active nonpeptide growth hormone secretagogue, MK-677, on 24-hour growth hormone profiles, insulin-like growth factor-I and adrenocortical function in normal young men. J Clin Endocrinol Metab 1996; 81: 2776–2782.

    Article  PubMed  CAS  Google Scholar 

  123. Ocampo-Lim B, Guo W, DeMott Friberg R, Barkan AL, Jaffe CA. Nocturnal growth hormone (GH) secretion is eliminated by infusion of GH- releasing Hormone antagonist. J Clin Endocrinol Metab 1996; 81: 4396–4399.

    Article  PubMed  CAS  Google Scholar 

  124. Mendelson WB, Sitaram N, Wyatt RJ, Gillin JC, Jacobs LS. Methscopolamine inhibition of sleep-related growth hormone secretion. J Clin Invest 1978; 1978: 1683–1690.

    Article  Google Scholar 

  125. Taylor BJ, Smith PJ, Brook GD. Inhibition of physiological growth hormone secretion by atropine. Clin Endocrinol 1985; 22: 497–501.

    Article  CAS  Google Scholar 

  126. Peters JR, Evans PJ, Page MD, Hall R, Gibbs JT, Dieguez C, Scanlon MF. Cholinergic muscarinic receptor blockade with pirenzepine abolishes slow-wave sleep-related growth hormone release in normal adult males. Clin Endocrinol 1986; 26: 213–217.

    Article  Google Scholar 

  127. McCracken JT, Poland RE, Rubin RT, Tondo L. Dose-dependent effects of scopolamine on nocturnal growth hormones secretion in normal adult men: relation to a-sleep changes. J Clin Endocrinol Metab 1991; 72: 90–95.

    Article  PubMed  CAS  Google Scholar 

  128. Mendelson WB, Lantigua R, Wyatt R, Gillin JC, Jacobs L. Piperidine enhances sleep-related and insulin-induced growth hormone secretion: further evidence for a cholinergic secretory mechanism. J Clin Endocrinol Metab 1981; 52: 409–415.

    Article  PubMed  CAS  Google Scholar 

  129. Parker DC, Rossman LG. Human growth hormone release in sleep: nonsuppression by acute hyperglycemia. J Clin Endocrinol Metab 1971; 32: 65–69.

    Article  PubMed  CAS  Google Scholar 

  130. Muller EE, Cella SG, Parenti M, Deghenghi R, Locatelli V, De Gennaro Colonna V, Torsello A, Cocchi D. Somatotropic dysregulation in old mammals. Horm Res 1995; 43: 39–45.

    Article  PubMed  CAS  Google Scholar 

  131. Chapman IA, Bach MA, Van Cauter E, Farmer M, Krupa D, Taylor AM, Schilling LM, Cole KY, Skyles EH, Pezzoli SS, Hartman ML, Veldhuis JD, Gormley GJ, Thorner MO. Stimulation of the growth hormone (GH)-insulin-like growth factor-I axis by daily oral administration of a GH secretagogue (MK-677) in healthy elderly subjects. J Clin Endocrinol Metab 1996; 81: 4249–4257.

    Article  PubMed  CAS  Google Scholar 

  132. Martha PM, Blizzard RM, Rogol AD. Atenolol enhances growth hormone release to exogenous growth hormone releasing hormone but fails to alter spontaneous growth hormone secretion in boys with constitutional delay of growth. Pediatr Res 1988; 23: 393–397.

    Article  PubMed  Google Scholar 

  133. Ghigo E, Imperiale E, Mazza E, Goffi S, Procopio M, Muller EE, Camanni F. Cholinergic enhancement by pyridostigmine potentiates diurnal but not nocturnal growth hormone secretion in short children. Neuroendocrinology 1989; 49: 134–137.

    Article  PubMed  CAS  Google Scholar 

  134. Ghigo E, Arvart E, Nicolosi M, Bellone J, Valetto MR, Mazza E, Imperiale E, Procopio M, Ghigo MC, Camanni F. Acute clonidine administration potentiates spontaneous diurnal, but not nocturnal, growth hormone secretion in normal short children. J Clin Endocrinol Metab 1990; 71: 433–435.

    Article  PubMed  CAS  Google Scholar 

  135. Obâl FJ, Payne L, Kapas L, Opp M, Alföldi P, Krueger JM. Growth hormone releasing hormone (GHRH) in sleep regulation. Sleep Res 1991; 20A: 192.

    Google Scholar 

  136. Krueger J, Obal FJ. Growth hormone-releasing hormone and interleukin-lin sleep regulation. FASEB J 1993; 7: 645–652.

    CAS  Google Scholar 

  137. Bredow S, Taishi P, Obal FJ, Guha-Thakurta N, Krueger JM. Hypothalamic growth hormone-releasing hormone MRNA varies across the day in rats. Neuroreport 1996; 7: 2501–2505.

    Article  PubMed  CAS  Google Scholar 

  138. Meister B, Hökfelt T. The somatostatin and growth hormone-releasing factor systems. In: Nemeroff CB, ed. Neuroendocrinology. CRC Press, Boca Raton, FL, 1992, pp. 219–278.

    Google Scholar 

  139. Veldhuis J, Liem A, South S, Weltman A, Weltman J, Clemmons D, Abbott R, Mulligan T, Johnson M, Pincus S, Straume M, Iranmanesh A. Differential impact of age, sex steroid hormones, and obesity on basal versus pulsatile growth hormone secretion in men as assessed in an ultrasensitive chemiluminescence assay. J Clin Endocrinol Metab 1995; 80: 3209–3222.

    Article  PubMed  CAS  Google Scholar 

  140. Cuneo R, Salomon F, McGauley G, Sonksen P. The growth hormone deficiency syndrome in adults. Clin Endocr 1992; 37: 387–397.

    Article  PubMed  CAS  Google Scholar 

  141. Corpas E, Harman SM, Blackman MR. Human growth hormone and human aging. Endocr Rev 1993; 14: 20–39.

    PubMed  CAS  Google Scholar 

  142. Rosen T, Hansson T, Granhed H, Szucs J, Bengtsson B. Reduced bone mineral content in adult patients with growth hormone deficiency. Acta Endocrinol 1993; 129: 201–206.

    PubMed  CAS  Google Scholar 

  143. Gaillard JM. Benzodiazepines and GABA-ergic transmission. In: Kryger MH, Roth T, Dement WC, ed. Principles and practice of sleep medicine. WB Saunders, Co, Philadelphia, 1994, pp. 349–354.

    Google Scholar 

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Authors
  1. Eve Van Cauter PhD
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  2. Georges Copinschi MD, PhD
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Editors and Affiliations

  1. Huffington Center on Aging and Department of Cell Biology, Baylor College of Medicine, Houston, TX, USA

    Roy G. Smith PhD

  2. Department of Medicine, University of Virginia Health Sciences Center, Charlottesville, VA, USA

    Michael O. Thorner MD

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Van Cauter, E., Copinschi, G. (2000). Interactions Between Growth Hormone Secretion and Sleep. In: Smith, R.G., Thorner, M.O. (eds) Human Growth Hormone. Contemporary Endocrinology, vol 19. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-015-5_16

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  • DOI: https://doi.org/10.1007/978-1-59259-015-5_16

  • Publisher Name: Humana Press, Totowa, NJ

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