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H. pylori-Related Diseases

Diagnosis and Treatment

  • Chapter
Diseases of the Gastroesophageal Mucosa

Part of the book series: Clinical Gastroenterology ((CG))

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Abstract

The aim of this chapter is to review appropriate diagnostic tests and current treatment strategies for Helicobacter pylori (H. pylori) infection. H. pylori has had an enormous impact on understanding and management of peptic ulcer disease (PUD). H. pylori infection is universally accepted as the commonest, although not the only, cause of PUD. Indeed the management of peptic ulcer now hinges on the characterization of the ulcer diathesis as H. pylori-positive or H. pylori-negative.

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References

  1. Howden CW, Hunt R H. (1998) Guidelines for the management of Helicobacter pylori infection. Am J Gastroenterol 93: 2330–2338.

    Article  PubMed  CAS  Google Scholar 

  2. Breuer T, Goodman KJ, Malaty, HM, et al. (1998) How do clinicians practicing in the U.S. manage Helicobacter pylori-related gastrointestinal diseases? A comparison of primary care and specialist physicians. Am J Gastroenterol 93: 553–561.

    Article  PubMed  CAS  Google Scholar 

  3. Sharma VK, Vasudeva R, Howden CW. (1999) A survey of gastroenterologists’ perceptions and practices related to Helicobacter pylori infection. Am J Gastroenterol 94: 3170–3174.

    Article  PubMed  CAS  Google Scholar 

  4. Howden CW, Sharma VK. (1999) What is the level of understanding of primary care providers regarding Helicobacter pylori? Gastroenterology 116: A94 (Abstract).

    Google Scholar 

  5. Sharma VK, Bailey DM, Raufman J-P, et al. (1999) A survey of internal medicine residents’ opinions and practices related to H. pylori. Am J Gastroenterol 94: 1647 (Abstract).

    Google Scholar 

  6. Howden CW. (2000) What causes H. pylori-negative non-NSAID related ulcers? In: Helicobacter pylori: Basic Mechanisms to Clinical Cure, 2000. ( Hunt RH, Tytgat GNJ, eds.), Dordrecht: Kluwer Scientific.

    Google Scholar 

  7. Cutler AF, Haystad S, Ma CK, et al. (1995) Accuracy of invasive and noninvasive tests to diagnose Helicobacter pylori infection. Gastroenterology 109: 136–141.

    Article  PubMed  CAS  Google Scholar 

  8. Cutler A, Schubert A, Schubert T. (1993) Role of Helicobacter pylori serology in evaluating treatment success. Dig Dis Sci 38: 2262–2266.

    Article  PubMed  CAS  Google Scholar 

  9. Marchildon P, Balaban DH, Sue M, et al. (1999) Usefulness of serological IgG antibody determination for confirming eradication of Helicobacter pylori infection. Am J Gastroenterol 94: 2105–2108.

    Article  PubMed  CAS  Google Scholar 

  10. Chey WD, Murthy U, Shaw S, et al. (1999) A comparison of three fingerstick, whole blood antibody tests for Helicobacter pylori infection: a United States, multicenter trial. Am J Gastroenterol 94: 1512–1516.

    Article  PubMed  CAS  Google Scholar 

  11. Logan RPH, Dill S, Bauer E, et al. (1991) The European 13C-urea breath test for the detection of Helicobacter pylori. Eur J Gastroenterol Hepatol 3: 915–921.

    Google Scholar 

  12. Peura DA, Pambianco DJ, Dye KR, et al. (1996) Microdose 14C-urea breath test offers diagnosis of Helicobacter pylori in 10 minutes. Am J Gastroenterol 91: 233–238.

    PubMed  CAS  Google Scholar 

  13. Slomianski A, Schubert T, Cutler AF. (1995) [13C]-urea breath test to confirm eradication of Helicobacter pylori. Am J Gastroenterol 90:224–227.

    Google Scholar 

  14. Laine L, Estrada R, Trujillo M, et al. (1998) Effect of proton-pump inhibitor therapy on diagnostic testing for Helicobacter pylori. Ann Intern Med 129: 547–550.

    PubMed  CAS  Google Scholar 

  15. Bravo LE, Realpe L, Campo C, et al. (1999) Effects of acid suppression and bismuth medications on the performance of diagnostic tests for Helicobacter pylori infection. Am J Gastroenterol 94: 2380–2383.

    Article  PubMed  CAS  Google Scholar 

  16. Sharma VK, Raufman J-P, Howden CW. (1999) To document or not to document H. pylori eradication after peptic ulcer hemorrhage? The cost question. Am J Gastroenterol 94: 2619 (Abstract).

    Google Scholar 

  17. Sharma VK, Raufman J-P, Howden CW. (1999) Is documentation of H. pylori eradication justifiable in patients with uncomplicated peptic ulcer? Am J Gastroenterol 94: 2619 (Abstract).

    Google Scholar 

  18. Cutler AF, Toskes P. (1999) Comparison of [13C] urea blood test to [13C] urea breath test for the diagnosis of Helicobacter pylori. Am J Gastroenterol 94: 959–961.

    Article  PubMed  CAS  Google Scholar 

  19. Chey WD, Murthy U, Toskes P, et al. (1999) The 13C-urea blood test accurately detects active Helicobacter pylori infection: a United States, multicenter trial. Am J Gastroenterol 94: 1522–1524.

    Article  PubMed  CAS  Google Scholar 

  20. Vaira D, Malfertheiner P, Mégraud F, et al. (1999) HpSA European study group. Diagnosis of Helicobacter pylori infection using a novel, non-invasive antigen-based assay. Lancet 354: 30–33.

    Article  PubMed  CAS  Google Scholar 

  21. Trevisani L, Sartori S, Ruina M, et al. (1999) Helicobacter pylori stool antigen test: Clinical evaluation and cost analysis of a new enzyme immunoassay. Dig Dis Sci 44: 2303–2306.

    Article  PubMed  CAS  Google Scholar 

  22. Lehmann F, Drewe J, Terracciano L, et al. (1999) Comparison of stool immunoassay with standard methods for detecting Helicobacter pylori infection. Br Med J 319: 1409.

    Article  CAS  Google Scholar 

  23. Oderda G, Rapa A, Ronchi B, et al. (2000) Detection of Helicobacter pylori in stool specimens by non-invasive antigen enzyme immunoassay in children: multicentre Italian study. Br Med J 320: 347–348.

    Article  CAS  Google Scholar 

  24. Laheij RJF, van Rossum LGM, Jansen JBMJ, et al. (1999) Evaluation of treatment regimens to cure Helicobacter pylori infection: a meta-analysis. Aliment Pharmacol Ther 13: 857–864.

    Article  PubMed  CAS  Google Scholar 

  25. Huang J-Q, Chiba N, Wilkinson JM, et al. (1997) Which combination therapy can eradicate 90% Helicobacter pylori infection? A meta-analysis of amoxicillin, metronidazole, tetracycline and clarithromycin-containing regimens. Gastroenterology 112: A19 (Abstract).

    Google Scholar 

  26. Peura DA. (1997) The report of the Digestive Health InitiativesM International Update Conference on Helicobacter pylori. Gastroenterology 113 (Suppl. 1): S4 - S8.

    Article  Google Scholar 

  27. Huang J-Q, Hunt RH. (1999) The importance of clarithromycin dose in the treatment of H. pylori infection: a meta-analysis of comparative studies of a proton pump inhibitor, amoxicillin, and clarithromycin. Gastroenterology 116: A65 (Abstract).

    Google Scholar 

  28. de Boer WA, Tytgat GNJ. (2000) Treatment of Helicobacter pylori infection. Br Med J 320: 31–34.

    Article  Google Scholar 

  29. Fennerty MB, Krause R, Huber M. (1998) A comparison of 10 and 14 days of lansoprazole triple therapy for eradication of H. pylori. Arch Intern Med 158: 1651–1656.

    Article  PubMed  CAS  Google Scholar 

  30. Laine L, Estrada R, Trujillo M, et al. (1996) Randomized comparison of twicea-day triple therapy for the eradication of Helicobacter pylori. Aliment Pharmacol Ther 10:1029–1033.

    Article  PubMed  CAS  Google Scholar 

  31. de Boer WA, van Etten RJXM, van de Wouw BAM, et al. (2000) Bismuth-based quadruple therapy for Helicobacter pylori: a single triple capsule plus lansoprazole. Aliment Pharmacol Ther 14: 85–89.

    Article  PubMed  Google Scholar 

  32. Laine L. (2000) Bismuth-based single capsule triple therapy in North America: Interim results of a North American study of OBMT vs. OAC. In: Helicobacter pylori: Basic Mechanisms to Clinical Cure, 2000. (Hunt RH, Tytgat GNJ, eds.), Dordrecht: Kluwer Scientific, in press.

    Google Scholar 

  33. Laine L, Malone T, Bochenek W, et al. (1999) Current U.S. rates of H. pylori antibiotic resistance and factors predicting resistance: results from ongoing trials at 77 sites. Gastroenterology 116: A228 (Abstract).

    Google Scholar 

  34. Huang J-Q, Hunt RH. (1999) Impact of metronidazole-resistant H. pylori strains on PPI-based triple therapies: a meta-analysis. Gastroenterology 116:A 191(Abstract).

    Google Scholar 

  35. Houben MHMG, van de Beek D, Hensen EF, et al. (1999) A systematic review of Helicobacter pylori eradication therapy–the impact of antimicrobial resistance on eradication rates. Aliment Pharmacol Ther 13: 1047–1055.

    Article  PubMed  CAS  Google Scholar 

  36. Fennerty MB, Lieberman DA, Vakil N, et al. (1999) Effectiveness of Helicobacter pylori therapies in a clinical practice setting. Arch Intern Med 159: 1562–1565.

    Article  PubMed  CAS  Google Scholar 

  37. Fennerty MB, Magaret N, Burn M, et al. (1999) Outcomes of treatment of H. pylori by community gastroenterologists: The GORGE II study. Gastroenterology 116: A57 (Abstract).

    Google Scholar 

  38. Sonnenberg A, Olson CA, Zhang J. (1999) The effect of antibiotic therapy on bleeding from duodenal ulcer. Am J Gastroenterol 94: 950–954.

    Article  PubMed  CAS  Google Scholar 

  39. Corder FA, Howden CW, Raufman J-P, et al. (1999) Helicobacter pylori eradication reduces the risk of recurrent peptic ulcer hemorrhage: a meta-analysis. Gastroenterology 116:A138–A139(Abstract).

    Google Scholar 

  40. Corder FA, Howden CW, Raufman J-P, et al. (1999) Helicobacter pylori eradication is superior to maintenance acid suppression for the prevention of recurrent peptic ulcer hemorrhage: ameta-analysis. Gastroenterology 116:A138(Abstract).

    Google Scholar 

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© 2001 Humana Press Inc., Totowa, NJ

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Howden, C.W. (2001). H. pylori-Related Diseases. In: Freston, J.W. (eds) Diseases of the Gastroesophageal Mucosa. Clinical Gastroenterology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-103-9_3

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  • DOI: https://doi.org/10.1007/978-1-59259-103-9_3

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4684-9642-0

  • Online ISBN: 978-1-59259-103-9

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