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Characterization of the HIV-1-Specific T-Helper Cell Response

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Retroviral Immunology

Part of the book series: Infectious Disease ((ID))

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Abstract

Human immunodeficiency virus type 1 (HIV-1) is associated with persistent and progressive infection in the majority of untreated persons, with an average time of 10 yr until the development of acquired immune deficiency syndrome (AIDS). However, longitudinal cohort studies have now identified persons who have been infected for >20 yr without the development of disease. In fact, a small number of untreated infected persons have maintained viral loads at or below the limits of detection by the most sensitive assays now available, normal CD4 cell counts, and have had no evidence of disease manifestations related to HIV. Other human viral infections such as Epstein—Barr virus (EBV) and Cytomegalovirus (CMV) persist for the life of an infected person, but are held in check by a persistent and effective immune response. The existence of persons with chronic controlled HIV-1 infection suggests that a state of immunologic control may be achievable in this infection as well.

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Authors
  1. Bruce D. Walker
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Editors and Affiliations

  1. Hospital de Beaumont, Lausanne, Switzerland

    Giuseppe Pantaleo MD

  2. Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Bruce D. Walker MD

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© 2001 Humana Press Inc., Totowa, NJ

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Walker, B.D. (2001). Characterization of the HIV-1-Specific T-Helper Cell Response. In: Pantaleo, G., Walker, B.D. (eds) Retroviral Immunology. Infectious Disease. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-110-7_10

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  • DOI: https://doi.org/10.1007/978-1-59259-110-7_10

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-128-8

  • Online ISBN: 978-1-59259-110-7

  • eBook Packages: Springer Book Archive

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