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Viral Mechanisms of Human Carcinogenesis

  • Chapter
The Molecular Basis of Human Cancer

Abstract

Within the last two decades of cancer research, it has become increasingly clear that viruses play an important role in the development of a significant percentage of human cancers. At present, it is recognized that viral infections are linked to at least 15% of all malignant tumors in humans and thus represent the second most common identified risk factor for cancer, exceeded only by tobacco smoking (1). Cancer-associated viruses are found in several virus families and encompass both DNA and RNA viruses (Table 1). In the past few years, significant progress has been made towards elucidation of the molecular mechanisms through which viruses contribute to cell transformation. Different tumor viruses target common cellular pathways for growth control, but also exhibit unique (virus-specific) properties that contribute to oncogenesis.

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  1. Felix Hoppe-Seyler MD
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  2. Karin Butz PhD
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  1. Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA

    William B. Coleman

  2. Department of Pathology and Laboratory Medicine, Hartford Hospital, Hartford, CT, USA

    Gregory J. Tsongalis

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Hoppe-Seyler, F., Butz, K. (2002). Viral Mechanisms of Human Carcinogenesis. In: Coleman, W.B., Tsongalis, G.J. (eds) The Molecular Basis of Human Cancer. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-125-1_12

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