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Chromosomes and Chromosomal Instability in Human Cancer

  • Chapter
The Molecular Basis of Human Cancer

Abstract

Many human cancers have chromosomal abnormalities, and frequently specific abnormalities are associated with specific forms of cancer. These findings have emerged gradually over the past 30 years as increasingly better techniques have become available for preparation and analysis of human chromosomes. Because of the ease with which leukemia cells can be obtained and analyzed, most studies of karyotypic abnormalities have been performed on hematopoietic malignancies. Initial studies simply characterized the gross chromosomal abnormalities occurring in different types of cancer cells. More recently, molecular rearrangements that are associated with many chromosomal abnormalities have been characterized in detail. These rearrangements frequently involve cellular protooncogenes or tumor-suppressor genes.

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Authors
  1. Takashi Shimamoto MD
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  2. Kazuma Ohyashiki MD
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Editors and Affiliations

  1. Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA

    William B. Coleman

  2. Department of Pathology and Laboratory Medicine, Hartford Hospital, Hartford, CT, USA

    Gregory J. Tsongalis

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Shimamoto, T., Ohyashiki, K. (2002). Chromosomes and Chromosomal Instability in Human Cancer. In: Coleman, W.B., Tsongalis, G.J. (eds) The Molecular Basis of Human Cancer. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-125-1_7

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  • DOI: https://doi.org/10.1007/978-1-59259-125-1_7

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-107-3

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