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Cytokines and Human Type 1 Diabetes

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Cytokines and Autoimmune Diseases

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Abstract

Although the immunological- and cytokine-mediated events preceding the development of full-blown Type 1 diabetes in the nonobese diabetic (NOD) mouse model are becoming better known, the events preceding disease in humans are less well-characterized. In human Type 1 diabetes, much effort has focused on establishing criteria for disease-development risk, which include genetic associations and the presence of autoantibodies. The contribution of human leukocyte antigen (HLA) alleles for susceptibility (HLA-DR3, HLA-DR4) or resistance (HLA-DQ8) to disease have been studied (reviewed in refs. 1–4). The diagnostic use of autoantibodies titers to isleT cell antigens such as glutamic acid decarboxylase (GAD) 65, insulin, and other antigens provide a risk assessment for disease onset (5). These markers, along with metabolic measurements, allow clinicians to track patients who are likely to develop disease and to provide support when disease development is imminent.

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Authors
  1. Sally C. Kent
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  2. Vissia Viglietta
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  3. David A. Hafler
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Editors and Affiliations

  1. Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Vijay K. Kuchroo DVM, PhD , David A. Hafler MD  & Lindsay B. Nicholson PhD, MB ,  & 

  2. Department of Immunology, Scripps Research Institute, La Jolla, CA, USA

    Nora Sarvetnick PhD

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© 2002 Humana Press Inc., Totowa, NJ

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Kent, S.C., Viglietta, V., Hafler, D.A. (2002). Cytokines and Human Type 1 Diabetes. In: Kuchroo, V.K., Sarvetnick, N., Hafler, D.A., Nicholson, L.B. (eds) Cytokines and Autoimmune Diseases. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-129-9_12

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  • DOI: https://doi.org/10.1007/978-1-59259-129-9_12

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-0-89603-856-1

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