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Immunologic Response to Renal Cell Carcinoma

  • Chapter
Renal Cell Carcinoma

Part of the book series: Current Clinical Oncology ((CCO))

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Abstract

Based on more than 50 years of intensive research, we have come to the understanding that the ability of a host to reject an established tumor lesion depends on whether a cellular antitumor immune response can be effectively generated and maintained in that individual (1–5). Murine tumor models readily demonstrated, that with few exceptions, the ability to confer protective antitumor immunity to naive mice is associated with the adoptive transfer of immune lymphocytes (6–10). In marked contrast, the adoptive transfer of serum from tumor-immune animals into naive mice failed to confer resistance to tumor progression (10,11). The critical nature of cellular antitumor immunity in the prevention and treatment of human malignancy has also been substantiated.

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  1. James H. Finke
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  1. Experimental Therapeutics, Cleveland Clinic Taussig Cancer Center, Cleveland, OH, USA

    Ronald M. Bukowski MD (Director) (Director)

  2. Department of Urology, Cleveland Clinic Foundation, Cleveland, OH, USA

    Andrew C. Novick MD (Chairman) (Chairman)

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Finke, J.H., Kierstead, L.S., Ranieri, E., Storkus, W.J. (2000). Immunologic Response to Renal Cell Carcinoma. In: Bukowski, R.M., Novick, A.C. (eds) Renal Cell Carcinoma. Current Clinical Oncology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-229-6_3

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