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Human and Animal Studies of the Genetics of Osteoporosis

  • Chapter
Osteoporosis

Part of the book series: Contemporary Endocrinology ((COE))

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Abstract

Osteoporosis is a disease characterized by an inadequate amount and/or faulty structure of bone, resulting in fractures from relatively minor trauma. Although, osteoporotic fractures are most commonly observed among the elderly, the pathogenesis of osteoporosis starts early in life and involves the interaction of multiple environmental and genetic factors (1,2). Considerable past research has centered on the influence of reproductive, nutritional and/or lifestyle factors on the development of osteoporosis. With the advent of new molecular genetic approaches, the focus of research has recently shifted towards genetic factors. Genetic epidemiological studies provide convincing descriptive data demonstrating population and ethnic differences. In addition, studies of familial aggregation, familial transmission patterns, and comparisons of twin concordance rates consistently identify a significant portion of the vulnerability to develop osteoporosis as being inherited. Almost certainly, the development of osteoporosis will be found to involve a complex interplay between both genetic and environmental factors.

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  1. Robert F. Klein MD
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Klein, R.F., Foroud, T. (2003). Human and Animal Studies of the Genetics of Osteoporosis. In: Orwoll, E.S., Bliziotes, M. (eds) Osteoporosis. Contemporary Endocrinology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-278-4_1

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