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Role of the Glutamatergic System in Opioid Tolerance and Dependence

Effects of NMDA Receptor Antagonists

  • Chapter
Glutamate and Addiction

Part of the book series: Contemporary Clinical Neuroscience ((CCNE))

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Abstract

The N-methyl-D-asparate (NMDA) receptor is a complex subtype of the glutamatergic receptor system. Glutamate and aspartate are endogenous ligands binding to NMDA receptors. Activation of NMDA receptors can be blocked at either the glutamate-binding site or the regulatory sites. Although the role of NMDA receptors in opioid tolerance and dependence was initially examined using t-opioid agonists, studies have been carried out to investigate the effects of NMDA receptor antagonists on tolerance and dependence induced by κ-and σ-opioid agonists.

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Authors
  1. Jianren Mao MD, PhD
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Editors and Affiliations

  1. Clinical Medical Branch, Division of Treatment Research and Development, National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), Bethesda, MD, USA

    Barbara H. Herman PhD

  2. Pharmacology, Integrative & Cellular Neurobiology Research Branch (PICNRB), Division of Neuroscience & Behavioral Research (DNBR), National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), Bethesda, MD, USA

    Jerry Frankenheim PhD

  3. Treatment Research Branch, Division of Clinical and Prevention Research, National Institute on Drug Abuse (NIAAA), National Institutes of Health (NIH), Bethesda, MD, USA

    Raye Z. Litten PhD

  4. Division of Neuropharmacological Drug Products Center for Drug Evaluation and Research, Office of Drug Evaluation I, Food and Drug Administration, Rockville, MD, USA

    Philip H. Sheridan MD

  5. Laboratory of Molecular and Cellular Neurobiology, Division of Intramural Clinical and Biological Research, National Institute on Drug Abuse (NIAAA) National Institutes of Health (NIH), Bethesda, MD, USA

    Forrest F. Weight MD

  6. Division of Treatment Research and Development, National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), Bethesda, MD, USA

    Steven R. Zukin MD

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Mao, J. (2002). Role of the Glutamatergic System in Opioid Tolerance and Dependence. In: Herman, B.H., Frankenheim, J., Litten, R.Z., Sheridan, P.H., Weight, F.F., Zukin, S.R. (eds) Glutamate and Addiction. Contemporary Clinical Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-306-4_19

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  • DOI: https://doi.org/10.1007/978-1-59259-306-4_19

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