Abstract
Histological analysis of soft-tissue specimens containing biomaterials is performed using the same techniques used for bone specimens containing implants. The reason for this is that routine histological microtomes cannot be used to section biomaterials and hard tissues, which have a hard-elastic texture. During histological preparation, this texture can lead to a fracture (gap) between the biomaterial and tissue. For this reason, specimens containing biomaterials and/or implants are embedded in hard plastic resins instead of paraffin. After fixing and embedding the specimen in hard resin, the procedure follows guidelines described in Chapters 18 and 23 for hard-tissue processing.
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Scarano, A., Favero, G.A., Fiera, E., Piattelli, A. (2003). Histological Analysis of Soft-Tissues Biomaterial Interface. In: An, Y.H., Martin, K.L. (eds) Handbook of Histology Methods for Bone and Cartilage. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-417-7_32
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DOI: https://doi.org/10.1007/978-1-59259-417-7_32
Publisher Name: Humana Press, Totowa, NJ
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Online ISBN: 978-1-59259-417-7
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