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Should All Adult Patients with Acute Lymphoblastic Leukemia in First Remission Undergo Allogeneic Bone Marrow Transplantation?

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Current Controversies in Bone Marrow Transplantation

Part of the book series: Current Clinical Oncology ((CCO))

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Abstract

Rapid clonal proliferation and accumulation of immature lymphocytes characterize acute lymphoblastic leukemia (ALL). Substantial progress in the cure rate achieved with chemotherapy (CT) has occurred in children with ALL, but results in adults remain poor (1). Significant progress in understanding the biology and heterogeneity of this disease has not yet led to significant improvement in outcome (2). This chapter critically reviews present treatment results in ALL, and presents a rationale for an aggressive treatment strategy.

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Authors
  1. Sam L. Penza MD
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  2. Edward A. Copelan MD
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Editors and Affiliations

  1. Bone Marrow Transplant Program, Department of Hematology/Medical Oncology, The Cleveland Clinic Foundation, Cleveland, OH, USA

    Brian J. Bolwell MD (Director, Staff Physician) (Director, Staff Physician)

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© 2000 Humana Press Inc., Totowa, NJ

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Penza, S.L., Copelan, E.A. (2000). Should All Adult Patients with Acute Lymphoblastic Leukemia in First Remission Undergo Allogeneic Bone Marrow Transplantation?. In: Bolwell, B.J. (eds) Current Controversies in Bone Marrow Transplantation. Current Clinical Oncology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-657-7_7

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  • DOI: https://doi.org/10.1007/978-1-59259-657-7_7

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4684-9812-7

  • Online ISBN: 978-1-59259-657-7

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