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Paget’s Disease of Bone

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Endocrinology of Aging

Part of the book series: Contemporary Endocrinology ((COE,volume 20))

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Abstract

Paget’s disease of bone (PDB; osteitis deformans) is a chronic disorder of localized increased bone remodeling, affecting 1.2–3.0% of people over 60 yr of age in the United States. The etiology of PDB is unknown, but current studies suggest that it may be caused by a latent paramyxovirus infection. Families have also been described with a high prevalence of PDB in multiple generations. Eighty percent of these families’ gene for PDB has been localized to the long arm of chromosome 18. PDB can have widely varying clinic manifestations. Symptoms of PDB depend on which part of the skeleton is involved. Bone pain, arthritic symptoms, deformity, neurological compression syndromes, fracture, and, rarely, malignant degeneration can occur in affected patients. When the diagnosis of PDB is considered, the patient should have a radioisotopic total body bone scan to localize areas of increased disease activity, then areas of increased tracer uptake should be radiographed to confirm the diagnosis. Serum markers of bone formation, such as alkaline phosphotase and bone-specific alkaline phosphotase, can be used to diagnose the disease, as well as monitor response to therapy. Urinary excretion of skeletal breakdown products (hydroxyproline, pyridinoline, N-telopeptides) are markers of bone resorption.

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Authors
  1. Dongjie Liu MD
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  2. Kenneth W. Lyles MD
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Editors and Affiliations

  1. Sciences Center, Saint Louis University Health, St. Louis, MO, USA

    John E. Morley MB, BCh  & Lucretia van den Berg MB, BCh  & 

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© 2000 Humana Press Inc., Totowa, NJ

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Liu, D., Lyles, K.W. (2000). Paget’s Disease of Bone. In: Morley, J.E., van den Berg, L. (eds) Endocrinology of Aging. Contemporary Endocrinology, vol 20. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-715-4_8

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  • DOI: https://doi.org/10.1007/978-1-59259-715-4_8

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-171-4

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