Skip to main content

Part of the book series: Current Clinical Practice ((CCP))

  • 1030 Accesses

Abstract

Mrs. J., a 58-year-old woman, views herself as health conscious. After smoking for 30 years, she quit smoking “cold turkey” almost 4 years ago. She sees her primary care physician (PCP) annually for a complete physical. During her most recent physical, Mrs. J. mentioned to her PCP that she has had a mild but persistent cough for the past 6 months and has lost 10 lb. over the last month. After further questioning, Mrs. J. reports that she occasionally sees red streaks in her sputum but this never lasts more than 2 to 3 days at a time. She attributes the coughing to dry air in her home. Her PCP orders a chest X-ray, which is remarkable for a suspicious spot on the right lung. Mrs. J. then undergoes chest computed tomography (CT) imaging, which shows a probable tumor with accompanying lympadenopathy. Mrs. J. undergoes a needle biopsy, which confirms a diagnosis of small-cell lung cancer (SCLC).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 119.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 159.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Jemal A, Tiwari R, Murray T, et al. Cancer statistics, 2004. CA Cancer J Clin 2004; 54:8–29.

    Article  PubMed  Google Scholar 

  2. United States Preventive Services Task Force. Lung cancer screening: Recommendation statement. Ann Intern Med 2004; 140:738.

    Google Scholar 

  3. Sundaresan V, Rabbits P. Genetics of lung tumors. In: Hasleton,ed. Spencer’s Pathology of the Lung, 5th Ed. McGraw-Hill, New York, 1996; pp. 975–1008.

    Google Scholar 

  4. Denlinger CE, Rundall BK, Jones DR. Modulation of antiapoptotic cell signaling pathways in non-small cell lung cancer: the role of NF-kappaB. Semin Thorac Cardiovasc Surg 2004; 16:28–39.

    Article  PubMed  Google Scholar 

  5. Massague J. G1 cell-cycle control and cancer. Nature 2004; 432:7015.

    Article  CAS  Google Scholar 

  6. Syrjanen KJ. HPV infections and lung cancer. J Clin Path 2002; 55:885–891.

    Article  PubMed  CAS  Google Scholar 

  7. Doll R, Hill AB. Smoking and carcinoma of the lung; preliminary report. BMJ 1950; 2:739.

    PubMed  CAS  Google Scholar 

  8. United States Department of Health and Human Services. The health consequences of smoking: a report of the Surgeon General. Washington, DC: USDHHS, Center for Disease Control. CDC Publication number 7829. Available from: http://www.cdc.gov/tobacco/sgr/sgr_2004/chapters.htm. Accessed: December 27, 2005.

  9. Mattson ME, et al. What are the odds that smoking will kill you? Am J Public Health 1987; 77:425.

    PubMed  CAS  Google Scholar 

  10. Crispo A, Brennan P, Jockel KH, et al. The cumulative risk of lung cancer among current, ex-and never-smokers in European men. Br J Cancer 2004; 91:1280–1286.

    Article  PubMed  CAS  Google Scholar 

  11. Villeneuve PJ, Mao Y. Lifetime probability of developing lung cancer, by smoking status, Canada. Can J Public Health 1994; 85:385–388.

    PubMed  CAS  Google Scholar 

  12. Rachet B, Siemiatycki J, Abrahamowicz M, Leffondre K. A flexible modeling approach to estimating the component effects of smoking behavior on lung cancer. J Clin Epidemiol 2004; 57:1076–1085.

    Article  PubMed  CAS  Google Scholar 

  13. Weinstein ND, Marcus SE, Moser RP. Smokers’ unrealistic optimism about their risk. Tob Control 2005; 14:55–59.

    Article  PubMed  CAS  Google Scholar 

  14. Baker F, Ainsworth SR, Dye JT, et al. Health risks associated with cigar smoking. JAMA 2000; 284:735–740.

    Article  PubMed  CAS  Google Scholar 

  15. Shapiro JA, Jacobs EJ, Thun MJ. Cigar smoking in men and risk of death from tobaccorelated cancers. J Natl Cancer Inst. 2000; 92:333–337.

    Article  PubMed  CAS  Google Scholar 

  16. Fontham ET, Correa P, Reynolds P, et al. Environmental tobacco smoke and lung cancer in nonsmoking women. A multicenter study. JAMA 1994; 271:1752–1759.

    Article  PubMed  CAS  Google Scholar 

  17. Janerich DT, Thompson WD, Varela LR, et al. Lung cancer and exposure to tobacco smoke in the household. N Engl J Med 1990; 323:632–636.

    Article  PubMed  CAS  Google Scholar 

  18. Grimsrud TK, Berge SR, Haldorsen T, Andersen A. Can lung cancer risk among nickel refinery workers be explained by occupational exposures other than nickel? Epidemiology 2005; 16:146–154.

    Article  PubMed  Google Scholar 

  19. Schrump D, Altorki N, et al. Cancer of the lung. In: DeVita V, Helman S, Rosenberg S, eds. Cancer: Principles and Practice of Oncology, 7th Ed. Lippincott, Williams, and Wilkins, New York, 2005, pp. 753–800.

    Google Scholar 

  20. Arcasoy SM, Jett JR. Superior pulmonary sulcus tumors and Pancoast’ s syndrome. N Engl JMed 1997; 337:1370–1377.

    Article  CAS  Google Scholar 

  21. Bajard A, Westeel V, Dubiez A, et al. Multivariate analysis of factors predictive of brain metastases in localised non-small cell lung carcinoma. Lung Cancer 2004; 45:317–323.

    Article  PubMed  CAS  Google Scholar 

  22. Lillington GA, Caskey CI. Evaluation and management of solitary and multiple pulmonary nodules. Clin Chest Med 1993; 14:111–119.

    PubMed  CAS  Google Scholar 

  23. Rolston KV, Rodriguez S, Dholakia N, Whimbey E, Raad I. Pulmonary infections mimicking cancer: a retrospective, three-year review. Support Care Cancer 1997; 5:90–93.

    Article  PubMed  CAS  Google Scholar 

  24. Rena O, Leutner M, Casadio C. Human pulmonary dirofilariasis: uncommon cause of pulmonary coin-lesion. Eur J Cardiothorac Surg 2002; 22:157–159.

    Article  PubMed  Google Scholar 

  25. Paik DS, Beaulieu CF, Rubin GD, et al. Surface normal overlap: a computer-aided detection algorithm with application to colonic polyps and lung nodules in helical CT. Trans Med Imaging 2004; 23:661–675.

    Article  Google Scholar 

  26. Ludwig C, Zeitoun M, Stoelben E. Video-assisted thoracoscopic resection of pulmonary lesions. Eur J Surg Oncol 2004; 30:1118–1122.

    Article  PubMed  CAS  Google Scholar 

  27. Midthun DE. Solitary pulmonary nodule: time to think small. Curr Opin Pulm Med 2000; 6:364–370.

    Article  PubMed  CAS  Google Scholar 

  28. Mountain CF. Revisions in the international system for staging lung cancer. Chest 1997; 111: 1710–1717.

    PubMed  CAS  Google Scholar 

  29. Scagliotti G. Consensus development conference on the medical treatment of non-small cell lung cancer: treatment of the early stages. Lung Cancer 2002; 38:S23–S29.

    Article  PubMed  Google Scholar 

  30. Scagliotti GV, De Marinis F, Rinaldi, M, et al. Phase III randomized trial comparing three platinum-based doublets in advanced non-small-cell lung cancer. J Clin Oncol 2002; 20: 4285–4291.

    Article  PubMed  CAS  Google Scholar 

  31. Popat S, O’brien M. Chemotherapy strategies in the treatment of small cell lung cancer. Anticancer Drugs 2005; 16:361–363.

    Article  PubMed  CAS  Google Scholar 

  32. United States Department of Health and Human Services (USDHHS). The health benefits of smoking cessation: a report of the Surgeon General. USDHHS, Washington, DC,.

    Google Scholar 

  33. Fontana R, Sanderson DR, et al. Screening for lung cancer: the Mayo program. J Occup Med 1986; 28:746.

    Article  PubMed  CAS  Google Scholar 

  34. Kubik A, Polak J. Lung cancer detection: results of a randomized prospective study in Czechoslovakia. Cancer 1986; 57:2427.

    Article  PubMed  CAS  Google Scholar 

  35. Melamed MR, Flehinger BJ, Zaman MB, Heelan RT, Perchick WA, Martini N. Screening for early cancer: results of the Memorial Sloan-Kettering study in New York. Chest 1984; 86:44–53.

    Article  PubMed  CAS  Google Scholar 

  36. Swensen SJ, Jett JR, et al. Lung cancer screening with CT: Mayo Clinic experience. Radiology 2003: 226:756–761.

    Article  PubMed  Google Scholar 

  37. United States Preventive Services Task Force. Lung cancer screening: recommendation statement. Ann Intern Med 2004; 140:738.

    Google Scholar 

  38. Pao W, Miller VA. Epidermal growth factor receptor mutations, small-molecule kinase inhibitors, and non-small-cell lung cancer: current knowledge and future directions. J Clin Oncol 2005; 23:2556–2568.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Humana Press Inc., Totowa, NJ

About this chapter

Cite this chapter

Raza, M.A., Mintz, M.L. (2006). Lung Cancer. In: Mintz, M.L. (eds) Disorders of the Respiratory Tract. Current Clinical Practice. Humana Press. https://doi.org/10.1007/978-1-59745-041-6_16

Download citation

  • DOI: https://doi.org/10.1007/978-1-59745-041-6_16

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-556-9

  • Online ISBN: 978-1-59745-041-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics