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mRNA Translation in Diabetic Nephropathy

  • Chapter
The Diabetic Kidney

Part of the book series: Contemporary Diabetes ((CDI))

Abstract

With the decoding of the human genome, there is an urgent need for greater understanding of how proteins are synthesized and how they function. This notion is predicated on the importance of proteins as ultimate arbiters of cell function. Studies restricted to investigation of changes in mRNA levels do not address changes in proteins and their function. A strict linear correlation between mRNA levels and proteins does not always exist (1,2). Therefore, it is imperative that protein metabolism be studied directly.

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Authors and Affiliations

  1. Department of Medicine, University of Texas Health Science Center, South Texas Veterans Health Care System, San Antonio, TX

    Balakuntalam S. Kasinath MD

  2. Department of Medicine, University of Texas Health Science Center, San Antonio, TX

    Myung Ja Lee PhD & Denis Feliers PhD

  3. Department of Biochemistry, McGill University, Montreal, Canada

    Nahum Sonenberg PhD

Authors
  1. Balakuntalam S. Kasinath MD
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  2. Myung Ja Lee PhD
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  3. Denis Feliers PhD
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  4. Nahum Sonenberg PhD
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Editor information

Editors and Affiliations

  1. Division of Nephrology and Hypertension, Department of Medicine, Henry Ford Hospital, Detroit, MI

    Pedro Cortes MD

  2. Department of Internal Medicine M (Diabetes and Endocrinology), Aarhus University Hospital, Aarhus, Denmark

    Carl Erik Mogensen MD

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© 2006 Humana Press Inc., Totowa, NJ

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Kasinath, B.S., Lee, M.J., Feliers, D., Sonenberg, N. (2006). mRNA Translation in Diabetic Nephropathy. In: Cortes, P., Mogensen, C.E. (eds) The Diabetic Kidney. Contemporary Diabetes. Humana Press. https://doi.org/10.1007/978-1-59745-153-6_6

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  • DOI: https://doi.org/10.1007/978-1-59745-153-6_6

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-624-5

  • Online ISBN: 978-1-59745-153-6

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