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Electrical Manipulation of DNA on Metal Surfaces

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NanoBioTechnology

Abstract

We review recent work on the active manipulation of DNA on metal substrates by electric fields. This includes the controlled positioning, alignment, or release of DNA on or into dedicated locations and the control of hybridization. In this context, we discuss techniques for immobilizing DNA on metal surfaces and methods of characterizing such hybrid systems. In particular, we focus on electrically induced, conformational changes of monolayers of short oligonucleotides on gold substrates. Such switchable layers allow for molecular dynamics studies at interfaces and have demonstrated large potential in label-free biosensing applications.

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Author information

Authors and Affiliations

  1. Institute of Semiconductor Technology, Technical University of Braunschweig, Braunschweig, Germany

    Marc Tornow

  2. Walter Schottky Institut, Technische Universitaet Muenchen, Garching, Germany

    Kenji Arinaga & Ulrich Rant

  3. Fujitsu Laboratories Ltd., Atsugi, Japan

    Kenji Arinaga

Authors
  1. Marc Tornow
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  2. Kenji Arinaga
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  3. Ulrich Rant
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Editors and Affiliations

  1. The Institute of Plant Science and Genetics in Agriculture and The Otto Warburg Center for Agricultural Biotechnology, The Hebrew University of Jerusalem, Rehovot, Israel

    Oded Shoseyov

  2. Intel Electronics, Intel Research Israel, Jerusalem, Israel

    Ilan Levy

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Tornow, M., Arinaga, K., Rant, U. (2008). Electrical Manipulation of DNA on Metal Surfaces. In: Shoseyov, O., Levy, I. (eds) NanoBioTechnology. Humana Press. https://doi.org/10.1007/978-1-59745-218-2_9

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