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Autograft Bone

  • Chapter
Musculoskeletal Tissue Regeneration

Part of the book series: Orthopedic Biology and Medicine ((OBM))

Abstract

Autograft is the gold standard for reconstructive orthopaedic surgery. Nonvascularized cortical autograft can provide structural support, and can become integrated around its periphery with bone in the insertion site, but is likely to remain largely necrotic and may eventually fracture. Vascularized cor tical autografts integrate well with surrounding bone, but are associated with considerable morbidity at the harvest site. Iliac crest autograft has excellent osteogenic and osteoconductive properties, and has proven to be efficacious in many surgical procedures. Tissue harvested locally at the time of a spine operation avoids the morbidity associated with harvesting iliac crest, but “local autograft” preparations may contain substantial proportions of fibrous tissue and fibrocartilage, and may not be as osteogenic as iliac crest. Recent studies suggest that aspirated bone marrow with enrichment of osteoblast precursor populations may be a useful addition to other bone graft extender materials. The efficacy of autogenous growth factors isolated from platelet preparations for skeletal reconstruction has yet to be fully demonstrated.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan

    Takaaki Fujishiro

  2. Departments of Pathology and Orthopaedic Surgery, The Cleveland Clinic Foundation, Cleveland, OH

    Hideo Kobayashi & Thomas W. Bauer

Authors
  1. Takaaki Fujishiro
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  2. Hideo Kobayashi
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  3. Thomas W. Bauer
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Editors and Affiliations

  1. Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, USA

    William S. Pietrzak Ph.D.

  2. Biomet, Inc., Warsaw, IN, USA

    William S. Pietrzak Ph.D.

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© 2008 Humana Press, a part of Springer Science+Business Media, LLC

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Fujishiro, T., Kobayashi, H., Bauer, T.W. (2008). Autograft Bone. In: Pietrzak, W.S. (eds) Musculoskeletal Tissue Regeneration. Orthopedic Biology and Medicine. Humana Press. https://doi.org/10.1007/978-1-59745-239-7_4

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  • DOI: https://doi.org/10.1007/978-1-59745-239-7_4

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-909-3

  • Online ISBN: 978-1-59745-239-7

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