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Drug–Nutrient Interactions in Rheumatic Diseases

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Nutrition and Rheumatic Disease

Part of the book series: Nutrition and Health ((NH))

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Summary

• Timing of medication in relation to mealtime influences absorption and bioavailability of drugs.

• Fish-oil supplementation can reduce prostaglandin production and proinflammatory cytokines.

• Nonsteroidal anti-inflammatory drug use can be modulated by fish-oil supplements.

• Folate status is important for prevention of methotrexate toxicity.

• Side effects of medication, pathological process of the disease, low appetite, and low mobility from active disease can contribute to poor nutritional status of patients with rheumatic disease.

• Optimal nutritional status should be maintained to achieve a positive treatment outcome and to reduce the risk for developing concurrent diseases.

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References

  1. Utermohlen V. Diet, nutrition, and drug interactions. In: Shils ME, Olson JA, Shike M, Ross AC (eds). Modern Nutrition in Health and Disease, 9th ed. Williams and Wilkins, Baltimore, MD 1999, PP. 1621–1641.

    Google Scholar 

  2. Fleisher D, Li C, Zhou Y, Pao LH, Karim A. Drug, meal and formulation interactions influencing drug absorption after oral administration. Clinical implications. Clin Pharmacokinet 1999;36:233–254.

    Article  PubMed  CAS  Google Scholar 

  3. Calder PC. n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Am J Clin Nutr 2006;83:1505S–1519S.

    PubMed  CAS  Google Scholar 

  4. Haagsma CJ, Blom HJ, van Riel PL, et al. Influence of sulphasalazine, methotrexate, and the combination of both on plasma homocysteine concentrations in patients with rheumatoid arthritis. Ann Rheum Dis 1999;58:79–84.

    PubMed  CAS  Google Scholar 

  5. Reid IR, Veale AG, France JT. Glucocorticoid osteoporosis. J Asthma 1994;31:7–18.

    Article  PubMed  CAS  Google Scholar 

  6. O’Dell JR. Therapeutic strategies for rheumatoid arthritis. N Engl J Med 2004;350:2591–2602.

    Article  PubMed  CAS  Google Scholar 

  7. Paulson SK, Vaughn MB, Jessen SM, et al. Pharmacokinetics of celecoxib after oral administration in dogs and humans: effect of food and site of absorption. J Pharmacol Exp Ther 2001;297:638–645.

    PubMed  CAS  Google Scholar 

  8. Klueglich M, Ring A, Scheuerer S, et al. Ibuprofen extrudate, a novel, rapidly dissolving ibuprofen formulation: relative bioavailability compared to ibuprofen lysinate and regular ibuprofen, and food effect on all formulations. J Clin Pharmacol 2005;45:1055–1061.

    Article  PubMed  CAS  Google Scholar 

  9. Pargal A, Kelkar MG, Nayak PJ. The effect of food on the bioavailability of ibuprofen and flurbiprofen from sustained release formulations. Biopharm Drug Dispos 1996;17:511–519.

    Article  PubMed  CAS  Google Scholar 

  10. von Schrader HW, Buscher G, Dierdorf D, Mugge H, Wolf D. Nabumetone—a novel anti-inflammatory drug: the influence of food, milk, antacids, and analgesics on bioavailability of single oral doses. Int J Clin Pharmacol Ther Toxicol 1983;21:311–321.

    Google Scholar 

  11. Kojima F, Kato S, Kawai S. Prostaglandin E synthase in the pathophysiology of arthritis. Fundam Clin Pharmacol 2005;19:255–261.

    Article  PubMed  CAS  Google Scholar 

  12. Egg D, Gunther R, Herold M, Kerschbaumer F. [Prostaglandins E2 and F2 alpha concentrations in the synovial fluid in rheumatoid and traumatic knee joint diseases]. Z Rheumatol 1980;39: 170–175.

    PubMed  CAS  Google Scholar 

  13. Beharka A, Wu D, Serafini M, Meydani S. Mechanism of vitamin E inhibition of cyclooxygenase activity in macrophages from old mice: role of peroxynitrite. Free Rad Biol Med 2002;32:503–511.

    Article  PubMed  CAS  Google Scholar 

  14. Geusens P, Wouters C, Nijs J, Jiang Y, Dequeker J. Long-term effect of omega-3 fatty acid supplementation in active rheumatoid arthritis. A 12-month, double-blind, controlled study. Arthritis Rheum 1994;37:824–829.

    Article  PubMed  CAS  Google Scholar 

  15. Fortin PR, Lew RA, Liang MH, et al. Validation of a meta-analysis: the effects of fish oil in rheumatoid arthritis. J Clin Epidemiol 1995;48:1379–1390.

    Article  PubMed  CAS  Google Scholar 

  16. MacLean C, Mojica W, SC M, et al. Effects of Omega-3 Fatty Acids on Lipids and Glycemin Control in Type II Diabetes and the Metabolic Syndrome and on Inflammatory Bowel Disease, Rheumatoid Arthritis, Renal Disease, Systemic Lupus Erythematosus, and Osteoporosis. Agency for Healthcare Research and Quality,Rockville, MD, 2004.

    Google Scholar 

  17. Cleland LG, Caughey GE, James MJ, Proudman SM. Reduction of cardiovascular risk factors with longterm fish oil treatment in early rheumatoid arthritis. J Rheumatol 2006;33:1973–1979.

    PubMed  CAS  Google Scholar 

  18. Irons R, Anderson MJ, Zhang M, Fritsche KL. Dietary fish oil impairs primary host resistance against Listeria monocytogenes more than the immunological memory response. J Nutr 2003;133:1163–1169.

    PubMed  CAS  Google Scholar 

  19. Byleveld PM, Pang GT, Clancy RL, Roberts DC. Fish oil feeding delays influenza virus clearance and impairs production of interferon-gamma and virus-specific immunoglobulin A in the lungs of mice. J Nutr 1999;129:328–335.

    PubMed  CAS  Google Scholar 

  20. Meydani SN, Meydani M, Verdon CP, Shapiro AA, Blumberg JB, Hayes KC. Vitamin E supplementation suppresses prostaglandine E2 synthesis and enhances the immune response of aged mice. Mech Ageing Dev 1986;34:191–201.

    Article  PubMed  CAS  Google Scholar 

  21. Wu D, Mura C, Beharka AA, et al. Age-associated increase in PGE2 synthesis and COX activity in murine macrophages is reversed by vitamin E. Am J Physiol 1998;275:C661–C668.

    PubMed  CAS  Google Scholar 

  22. Abate A, Yang G, Dennery PA, Oberle S, Schroder H. Synergistic inhibition of cyclooxygenase-2 expression by vitamin E and aspirin. Free Radic Biol Med 2000;29:1135–1142.

    Article  PubMed  CAS  Google Scholar 

  23. Edmonds SE, Winyard PG, Guo R, et al. Putative analgesic activity of repeated oral doses of vitamin E in the treatment of rheumatoid arthritis. Results of a prospective placebo controlled double blind trial. Ann Rheum Dis 1997;56:649–655.

    Article  PubMed  CAS  Google Scholar 

  24. Brennan FM, Maini RN, Feldmann M. Role of pro-inflammatory cytokines in rheumatoid arthritis. Springer Semin Immunopathol 1998;20:133–147.

    Article  PubMed  CAS  Google Scholar 

  25. Eastgate JA, Symons JA, Wood NC, Grinlinton FM, di Giovine FS, Duff GW. Correlation of plasma interleukin 1 levels with disease activity in rheumatoid arthritis. Lancet 1988;2:706–709.

    Article  PubMed  CAS  Google Scholar 

  26. Dinarelllo CA, Moldawer LL. Proinflammatory and Anti-inflammatory Cytokines in Rheumatoid Arthritis: A Primer for Clinicians, 2nd ed. Amgen, Thousand Oaks, CA, 2000.

    Google Scholar 

  27. Feldmann M, Maini RN. Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned– Annu Rev Immunol 2001;19:163–196.

    Google Scholar 

  28. Maini RN, Feldmann M. How does infliximab work in rheumatoid arthritis– Arthritis Res 2002;4(suppl 2):S22–S28.

    Google Scholar 

  29. Winthrop KL. Risk and prevention of tuberculosis and other serious opportunistic infections associated with the inhibition of tumor necrosis factor. Nat Clin Pract Rheumatol 2006;2:602–610.

    Article  PubMed  CAS  Google Scholar 

  30. Endres S, Ghorbani R, Kelley VE, et al. The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. N Engl J Med 1989;320:265–271.

    Article  PubMed  CAS  Google Scholar 

  31. Meydani SN, Lichtenstein AH, Cornwall S, et al. Immunologic effects of national cholesterol education panel Step-2 diets with and without fish-derived n-3 fatty acid enrichment. J Clin Invest 1993;92:105–113.

    Article  PubMed  CAS  Google Scholar 

  32. Kremer JM, Lawrence DA, Petrillo GF, et al. Effects of high-dose fish oil on rheumatoid arthritis after stopping nonsteroidal antiinflammatory drugs. Clinical and immune correlates. Arthritis Rheum 1995;38:1107–1114.

    Article  PubMed  CAS  Google Scholar 

  33. Dupuis LL, Koren G, Silverman ED, Laxer RM. Influence of food on the bioavailability of oral methotrexate in children. J Rheumatol 1995;22:1570–1573.

    PubMed  CAS  Google Scholar 

  34. Berkun Y, Levartovsky D, Rubinow A, et al. Methotrexate related adverse effects in patients with rheumatoid arthritis are associated with the A1298C polymorphism of the MTHFR gene. Ann Rheum Dis 2004;63:1227–1231.

    Article  PubMed  CAS  Google Scholar 

  35. Morgan SL, Baggott JE, Vaughn WH, et al. Supplementation with folic acid during methotrexate therapy for rheumatoid arthritis. A double-blind, placebo-controlled trial. Ann Intern Med 1994;121:833–841.

    PubMed  CAS  Google Scholar 

  36. Hoekstra M, van Ede AE, Haagsma CJ, et al. Factors associated with toxicity, final dose, and efficacy of methotrexate in patients with rheumatoid arthritis. Ann Rheum Dis 2003;62:423–426.

    Article  PubMed  CAS  Google Scholar 

  37. Ortiz Z, Shea B, Suarez Almazor M, Moher D, Wells G, Tugwell P. Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis. Cochrane Database Syst Rev 2000:CD000951.

    Google Scholar 

  38. Charland SL, Bartlett DL, Torosian MH. A significant methotrexate-glutamine pharmacokinetic interaction. Nutrition 1995;11:154–158.

    PubMed  CAS  Google Scholar 

  39. Fox AD, Kripke SA, De Paula J, Berman JM, Settle RG, Rombeau JL. Effect of a glutamine-supplemented enteral diet on methotrexate-induced enterocolitis. JPEN J Parenter Enteral Nutr 1988;12:325–331.

    PubMed  CAS  Google Scholar 

  40. Lin CM, Abcouwer SF, Souba WW. Effect of dietary glutamate on chemotherapy-induced immunosuppression. Nutrition 1999;15:687–696.

    Article  PubMed  CAS  Google Scholar 

  41. Rennie KL, Hughes J, Lang R, Jebb SA. Nutritional management of rheumatoid arthritis: a review of the evidence. J Hum Nutr Diet 2003;16:97–109.

    Article  PubMed  CAS  Google Scholar 

  42. Kamanli A, Naziroglu M, Aydilek N, Hacievliyagil C. Plasma lipid peroxidation and antioxidant levels in patients with rheumatoid arthritis. Cell Biochem Funct 2004;22:53–57.

    Article  PubMed  CAS  Google Scholar 

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© 2008 Humana Press, Totowa, NJ

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Han, S.N. (2008). Drug–Nutrient Interactions in Rheumatic Diseases. In: Coleman, L.A. (eds) Nutrition and Rheumatic Disease. Nutrition and Health. Humana Press. https://doi.org/10.1007/978-1-59745-403-2_4

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  • DOI: https://doi.org/10.1007/978-1-59745-403-2_4

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-976-5

  • Online ISBN: 978-1-59745-403-2

  • eBook Packages: MedicineMedicine (R0)

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